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High purity cortex fraxini and its preparation method

A technology of fennecin and its extract, which is applied in the field of high-purity fennecin and its preparation, can solve the problems of liver damage, troublesome operation, environmental pollution, etc., and achieve the effects of avoiding damage, simple operation and high purity

Active Publication Date: 2007-05-02
SHANGHAI SINE PHARMA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, 95% ethanol and ethyl acetate are used, the cost is high, and the extraction process is easy to emulsify, and the operation is troublesome
Moreover, there are great difficulties in the concentration step, because the solution volume is too small, the viscosity is too high, and it is difficult to separate crystals
In addition, and containing a large amount of feudaletine in the obtained feudaletine crystal, the purity is not ideal
[0004] In addition, in the existing method of extracting teretin, ethyl acetate is usually used for extraction. If the operator is exposed to ethyl acetate for a long time in the work project, it will cause harm to the human body, such as liver damage, etc., and will also affect the human body. environmental pollution

Method used

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preparation example Construction

[0011] The present invention provides a preparation method of aurecetine, said method comprising the steps of extracting aurecetine from arborescens, separation, concentration and crystallization, wherein the separation step is the following column chromatography step:

[0012] a) centrifuge or filter the extract obtained in the extraction step, and directly add the filtrate or supernatant to the macroporous adsorption resin column, wherein the weight-to-volume ratio of the raw material of Qinpi and the resin is 1:2 to 1:3; b) all the extracts to be extracted After passing through the resin column, elute with eluent. After the eluate is clarified, start to collect the eluate, and stop collecting until 10-15 times the column volume of the eluate is collected.

[0013] In the method of the present invention, the extraction step is conventional in the art. For example, the specific process of the extraction step can be carried out as follows:

[0014] 1) Pulverize the traditiona...

Embodiment 1

[0028] Add 10 liters of water to 1 kg of Qinpi coarse powder (place of origin: Gansu) (20 mesh), and heat and reflux for extraction for 1 hour. Then the residue was extracted twice with water, each time adding 8 liters of water, and the reflux time was 1 hour. The extracts were combined, and the resulting extracts were directly added to 1 kg of 2000 ml AB-8 resin column (chemical plant of Nankai University, Tianjin, styrene type), and loaded with 3 column volumes per hour. After the sample is loaded, elute with 30 liters of water. After the eluate is clarified, start to collect the eluate, and stop collecting until 20 liters of eluate are collected. The collected 20 liters of eluate was concentrated to 1 liter and then left overnight in the refrigerator. The next day, filter the refrigerated concentrate and wash the filter cake with a little water. Then, the filter cake was dissolved by heating with 1 liter of water, and the resulting solution was placed in a refrigerator fo...

Embodiment 2

[0030] Add 10 liters of water to 1 kg of Qinpi coarse powder (origin: Gansu) (20 mesh), and heat and reflux for extraction for 1.5 hours. Then the residue was extracted with water three times, adding 8 liters of water each time, and refluxed for 1 hour. The extracts were combined, and the obtained extracts were directly added to 3000 ml of Diaion HP-20 resin (produced by Mitsubishi Corporation, styrene type), and the sample was loaded at 3 column volumes per hour. After loading the sample, use 60 liters of water to elute. After the eluate is clarified, start to collect the eluate, and stop collecting until 40 liters of eluate are collected. The collected 40 liters of eluate was concentrated to 1 liter, and the concentrate was placed in the refrigerator overnight. The next day, filter the refrigerated concentrate and wash the filter cake with a little water. Then, the filter cake was dissolved by heating with 1 liter of water, and the resulting solution was placed in a refrig...

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PUM

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Abstract

This invention provides a preparation of aesculin. The mentioned preparation includes steps such as: extraction, column chromatography, concentration and crystallization. Among them the step of column chromatography is as following: a) centrifugalize or filter extract which is obtained in extracting step, filter liquor or clear supernatant liquid is directly added into macroporous resin column, among them the proportion by weight of cortex medical material and resin is 1:2-1:3;b) After all of the extract pass resin column, use eluting reagent to elute, after elutriant has clarified, begin to collect elutriant, don't stop collecting until collecting 10-15 times of elutriant of column volume.

Description

technical field [0001] The present invention relates to high-purity fruticelin and its preparation method. Background technique [0002] Qinpi is a commonly used traditional Chinese medicine, usually derived from the dry bark or dry bark of Fraxinusrhynchophylla Hanee, Fraxinus chinensis Roxb, Fraxinusszaboana Lingelsh. or Fraxinus stylosaLing of Oleaceae plants. The theory of traditional Chinese medicine believes that Qinpi has the functions of clearing away heat and dampness, reducing astringency, and improving eyesight. Modern research shows that Qinpi has anti-pathogenic microorganisms, anti-inflammatory, diuretic, anti-coagulant and anti-allergic effects. The main components of fennecin are coumarins, including fendecin, fendecin B, fencetine, etc., of which fendecin has the highest content, about 1%. [0003] At present, 95% ethanol reflux extraction method is used for the preparation of fencetin, which includes concentrating the extract until it has no alcohol smell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/76
Inventor 杨保华雷仕庆郭雅琦乌旭琼夏凌云
Owner SHANGHAI SINE PHARMA LAB
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