Microarray for assessing neuroblastoma prognosis and method of assessing neuroblastoma prognosis

A neuroblastoma, microarray technology, applied in the field of neuroblastoma prognosis diagnosis

Inactive Publication Date: 2006-11-01
CHIBA PREFECTURE +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, studies using microarrays of multiple neuroblastoma samples to predict prognosis have not been reported

Method used

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  • Microarray for assessing neuroblastoma prognosis and method of assessing neuroblastoma prognosis
  • Microarray for assessing neuroblastoma prognosis and method of assessing neuroblastoma prognosis
  • Microarray for assessing neuroblastoma prognosis and method of assessing neuroblastoma prognosis

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Experimental program
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Embodiment

[0079] 1. Materials and methods

[0080] 1-1. Patients and tumor specimens

[0081]The tumor specimens were fresh frozen tissues sent to Chiba Cancer Center Research Institute (Division of Biochemistry, Chiba Cancer Center Research Institute) from many hospitals in Japan. Informed Consent was obtained in various research institutes and hospitals. Almost all specimens were removed by preoperative biopsy or surgery, and chemotherapy or radiation therapy was not used. After the operation, the patient was treated according to the mutual agreement described in the literature (Kaneko, M. et al. Med. Pediatr Oncol 31, 1-7 (1998). About the copy number of the MYCN gene, TrkA gene expression, and DNA ploidy The biological information of each tumor is analyzed by the inventor’s laboratory. The tumors are all classified according to the International Neuroblastoma Staging System (INSS), as follows:

[0082] Stages 1 and 2: localized neuroblastoma

[0083] Stages 3 and 4: Local and local prol...

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Abstract

A microarray for assessing prognosis of neuroblastoma having 25 to 45 good prognosis probes selected from among 96 polynucleotides which are hybridizable with a gene transcriptional product showing accelerated expression in patients showing good prognosis of neuroblastoma and comprise the base sequence represented by SEQ ID NOS:1 to 96, partial consecutive sequences thereof or complementary chains of the same, and 25 to 45 poor prognosis probes selected from among 104 polynucleotides which are hybridizable with a gene transcriptional product showing accelerated expression in patients showing poor prognosis of neuroblastoma and comprise the base sequence represented by SEQ ID NOS:97 to 200, partial consecutive sequences thereof or complementary chains of the same.

Description

Technical field [0001] The invention of this application relates to a microarray for prognostic diagnosis of neuroblastoma. Specifically, the invention of the present application relates to a microarray for molecular biology diagnosis of the prognosis of patients with neuroblastoma after treatment, and a neuroblastoma prognostic diagnosis method using the microarray. Background technique [0002] Neuroblastoma (Neuroblastoma) is the most common type of solid tumor in children, originating from the sympathetic adrenal gland series of the neural crown (Bolade, 1974: Non-Patent Document 1). The clinical manifestations are not uniform. Neonatal tumors often resolve spontaneously due to differentiation-induced and / or programmed cell death, but tumors in patients over one year old are aggressive and often resist intensive treatment. Recently, although the survival rate has improved with the improvement of the treatment strategy of advanced neuroblastoma, the long-term effect is still v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/11C12Q1/68
CPCC12Q1/6886C12Q1/6837C12Q2600/118C12Q2600/158
Inventor 中川原章大平美纪石井信后藤武久保浩之平田隆洋吉田安子山田佐一
Owner CHIBA PREFECTURE
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