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Preparation method of erigeron breviscapus glucese injection

A technology of glucose injection and breviscapine, applied in the field of medicine, can solve problems such as unqualified, and achieve the effects of stable curative effect, good stability and less irritation

Active Publication Date: 2006-09-13
吉林四长制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The general process is to add disodium hydrogen phosphate solution to promote the dissolution of breviscapine, and then add disodium edetate, etc., but most of them cannot be produced and marketed because of the unqualified related substances of the preparation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of embodiment 1-breviscapine glucose injection

[0032] prescription:

[0033] (a) Breviscapine 2.5g

[0034] (b) Glucose 45g

[0035] (c) Disodium edetate 0.5g

[0036] (d) Activated carbon 3g for glucose treatment

[0037] (e) 1 g of activated carbon for disodium EDTA

[0038] (f) Add fresh water for injection to 1000ml

[0039] A) Take 200ml of fresh water for injection at 80°C, cool down to 30°C, add breviscapine, stir well, adjust to completely dissolved with 20% disodium hydrogen phosphate solution, control the pH to 2.0, and refrigerate at 4°C for 12 hours , filter with pulp, and then ultrafilter with an ultrafilter with a molecular weight cut-off of 100,000, and then ultrafilter with a poll type ultrafilter with a molecular weight cut-off of 10,000 to obtain the breviscapine ultrafiltrate.

[0040] B) Take 200ml of fresh water for injection at 80°C, add disodium ethylenediaminetetraacetate, stir well to dissolve completely, add ...

Embodiment 2

[0043] The preparation of embodiment 2-breviscapine glucose injection

[0044] prescription:

[0045] (a) Breviscapine 4g

[0046] (b) Glucose 45g

[0047] (c) Disodium edetate 0.5g

[0048] (d) Activated carbon 3g for glucose treatment

[0049] (e) 1 g of activated carbon for disodium EDTA

[0050] (f) Add fresh water for injection to 1000ml

[0051] A) Take 200ml of fresh water for injection at 85°C, cool down to 30°C, add breviscapine, stir well, adjust to completely dissolved with 20% disodium hydrogen phosphate solution, control the pH to 2.0, and refrigerate at 4°C for 12 hours , filter with pulp, and then ultrafilter with an ultrafilter with a molecular weight cut-off of 100,000, and then ultrafilter with a poll type ultrafilter with a molecular weight cut-off of 10,000 to obtain the breviscapine ultrafiltrate.

[0052]B) Take 200ml of fresh water for injection at 80°C, add disodium ethylenediaminetetraacetate, stir well to dissolve completely, add...

Embodiment 3

[0055] The preparation of embodiment 3-breviscapine glucose injection

[0056] prescription:

[0057] (a) Breviscapine 2.5g

[0058] (b) Glucose 40g

[0059] (c) Disodium edetate 0.5g

[0060] (d) Activated carbon 3g for glucose treatment

[0061] (e) 1 g of activated carbon for disodium EDTA

[0062] (f) Add fresh water for injection to 1000ml

[0063] A) Take 200ml of fresh water for injection at 80°C, cool down to 30°C, add breviscapine, stir well, adjust to completely dissolved with 20% disodium hydrogen phosphate solution, control the pH to 2.0, and refrigerate at 4°C for 12 hours , filter with pulp, and then ultrafilter with an ultrafilter with a molecular weight cut-off of 100,000, and then ultrafilter with a poll type ultrafilter with a molecular weight cut-off of 10,000 to obtain the breviscapine ultrafiltrate.

[0064] B) Take 200ml of fresh water for injection at 80°C, add disodium ethylenediaminetetraacetate, stir well to dissolve completely, a...

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PUM

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Abstract

A breviscapine-glucose injection for treating apoplexy sequelae, coronary heat disease and angina pectoris is prepared through depositing breviscapine in acid, cold storage, ultrafiltration, mixing with Na2EDTA, pouring in containers, sterilizing and lamp examining.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an injection, in particular to an injection containing breviscapine and glucose, a flavonoid substance extracted from the traditional Chinese medicine breviscapine. Background technique [0002] The incidence of cardiovascular and cerebrovascular diseases has remained high and is on the rise, which has become a worldwide problem. [0003] Erigeron breviscapus is the dry whole plant of Asteraceae breviscapita, mainly containing flavonoids, lactones, volatile oils, amino acids, etc. Breviscapine is one of the flavonoids, which can reduce the content of platelets in thrombus, and reduce the destruction of platelets and the release of 5-hydroxytryptamine. The production of -PEG1α can be inhibited; breviscapine can also significantly reduce cerebrovascular resistance and peripheral blood pressure; in addition, breviscapine can also increase coronary flow, increase the content of cAMP ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/08A61P9/10
Inventor 张玉梅
Owner 吉林四长制药有限公司
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