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Application of Extractive of Abarema elliptica in use for preparing antiallergic medication, food and cosmetic

A technology of monkey earrings and extracts, applied in medical preparations containing active ingredients, drug combinations, allergic diseases, etc., can solve the problems of monkey earrings without any application in anti-allergic systems

Inactive Publication Date: 2006-07-05
SHANHE PHARMA GUANGZHOU CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on the application of the anti-allergic system of monkey earrings.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment one: the preparation of monkey earring extract

[0023] Take 100g of dried monkey earring leaves, add 2000ml of 90°C hot water to extract for 5 minutes. After the extract is filtered through gauze, the filtrate is centrifuged at 1000 rpm for 5 minutes, and the supernatant is recovered and freeze-dried. The above freeze-dried extract of monkey earring leaf was used in the following examples of the present invention.

Embodiment 2

[0024] Example 2: The effect of monkey earring extract on mouse ear contact dermatitis caused by DNFB

[0025] The experimental method refers to the literature (Claman HN. and Jaffee BD.: Desensitization of contact allergy to DNFB in mice. I. Description of a model system. J. Immunol., 131: 2682-2686, 1983.), using males aged 7 weeks Kunming mice were bred for one week before the experiment. Ten mice / group were subcutaneously injected with 100 μl of 1.5% 2,4-DNFB (1-fluor-2,4-dinitro-benzene: DNFB, Merck) ethanol solution on the back as antigen for sensitization. Sensitization was established 5 days after the injection of 2,4-DNFB, and on the 6th day, 1% 2,4-DNFB-olive oil solution was applied to the right ear of the mouse as an antigen challenge to cause ear contact dermatitis in the mouse . After 24 hours, the edge of the ear was removed with a puncher with a diameter of 8 mm, and the weight difference of the edge of the ear / 8 mm was measured and the degree of edema was co...

Embodiment 3

[0027] Example 3: Effect of Monkey Earring Extract on DNFB-induced Hypervascular Leakage of Ear Contact Dermatitis in Mice

[0028] As described in Example 2, 1% 2,4-DNFB-olive oil solution was used as an antigen to attack for 23 hours, and 1% Evans blue (Evans blue) physiological salt was injected into the mouse tail vein according to the dose of 0.1ml / 10g body weight. aqueous solution. One hour after the injection of Evansland normal saline, the ear edge was removed with a hole punch with a diameter of 8 mm, referring to the katayama method (A new method for extracting of extravasated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guineapigs and rats .Microbiol.Immunol., 22:89-101, 1978.), put the ear edge into 1ml of 1N KOH aqueous solution, after soaking for 24 hours at 37°C, add 9ml of 0.6N phosphoric acid-acetone (5:13) solution, Centrifuge after fully stirring (3000rpm / 15 minutes). Take out the supernatant and measure the absor...

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PUM

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Abstract

An application of the extract of pithecellobium clypearia benth / archidendron clypearia Jack. Nielsen in preparing food, cosmetics and medicines for treating allergic dermatitis, allergic rhinitis, allergic pharyngitis, pollen anaphylaxis and other allergic diseases is disclosed.

Description

Technical field: [0001] The invention relates to the field of natural plant extraction and application. Background technique: [0002] In recent years, epidemiological investigations show that allergic diseases have been increasing year by year, especially the increasing trend of allergic reactions caused by environmental factors such as allergic dermatitis, allergic rhinitis, hay fever, allergic pharyngitis, etc. social phenomenon. The emergence of its problems is not only due to the increase of allergens, air pollution, and abuse of food additives, but also due to changes in people's eating habits in recent years. The treatment of allergic diseases is usually based on the elimination of allergens, and then selective drug treatment is carried out according to the degree, cause and pathogenesis of clinical symptoms. Allergic reactions are generally divided into 4 types according to the differences in immunoglobulins and related cells that cause clinical diseases. Type I~I...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P37/08A61P11/02A61K135/00A61K127/00
Inventor 吴蓉蓉黄杰昌栗原博续洁琨
Owner SHANHE PHARMA GUANGZHOU CITY
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