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Eye medicine prepn of effective shellfish component and its use

A technology of active ingredients and shellfish meat, applied in the directions of active ingredients of hydroxyl compounds, drug combinations, sensory diseases, etc., can solve the problems of undiscovered and complex shellfish meat active ingredients, and achieve the effects of correcting vision, reducing myopia, and promoting metabolism.

Inactive Publication Date: 2006-05-17
北海蓝海洋生物药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the active ingredients contained in shellfish are relatively complex, and the existing research is not enough to cover all the medicinal value of shellfish, which still leaves room for further research
For example, extracting active ingredients from shellfish meat for the treatment of ophthalmic diseases has not been reported in the literature and publicly used.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A, preparation of shellfish hydrolyzate:

[0023] Take 100 grams of net pearl oyster meat and mix it with 50 grams of water to form a meat slurry liquid, add 0.3 grams of trypsin and adjust to pH 4.5-7.5, hydrolyze at a temperature of 45-75 ° C for 8 -12 hours, filtered to obtain a filtrate, concentrated to a nitrogen content of no less than 20 mg / ml, and a taurine content of no less than 10 mg / ml, and filtered to obtain a shellfish hydrolyzate. The above-mentioned shellfish hydrolyzate can be prepared by using triangle clam meat, meretrix meretrix or oyster meat instead of pearl shellfish meat.

[0024] B. Preparation of eye drops:

[0025] Prescription: shellfish hydrolyzate 10ml borneol 0.5g

[0026] Chitosan 5g Sodium chloride 0.5g

[0027] Preparation method: First take sodium chloride, chitosan and 500 ml of water and stir evenly, then add 5 g of boric acid-borax pH adjustment recoil agent, stir evenly and heat to boiling, add shellfish hydrolyzate and mi...

Embodiment 2

[0030] Prescription: shellfish hydrolyzate 10ml borneol 1.5g

[0031] Chitosan 20g Sodium Chloride 10g

[0032] Preparation method: firstly take sodium chloride, chitosan and 500 ml of water and stir evenly, then add 10 g of citric acid-sodium citrate pH adjustment recoil agent, stir evenly and heat to boiling, add shellfish hydrolyzate and mix evenly to obtain When the mixture is cooled to 60°C, borneol and preservatives are added in a conventional amount, stirred evenly, adjusted to pH 4.5-9, filtered, and then added with water to 1000 ml to obtain the eye drops of the present invention.

[0033] The present invention can treat acute and chronic conjunctivitis, keratitis, electro-optic ophthalmia, visual fatigue, juvenile pseudomyopia and early prevention and treatment of cataract by local administration to eyes.

Embodiment 3

[0035] Prescription: shellfish hydrolyzate 10ml borneol 1.5g

[0036] Chitosan 50g Sodium Chloride 15g

[0037] Preparation method: First take sodium chloride, chitosan and 500 ml of water and stir evenly, then add 2 grams of boric acid-borax pH adjustment recoil agent, stir evenly and heat to boiling, add shellfish hydrolyzate and mix evenly to obtain a mixed solution when it is cooled to 80°C , when cooled to 60°C, add borneol and add preservative according to the conventional amount, stir evenly, adjust the pH value to 4.5-9, filter, add water to 1000 ml to obtain the eye drops of the present invention.

[0038] The present invention can treat acute and chronic conjunctivitis, keratitis, electro-optic ophthalmia, visual fatigue, juvenile pseudomyopia and early prevention and treatment of cataract by local administration to eyes.

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PUM

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Abstract

The present invention discloses eye medicine preparation with effective component extracted from shellfish meat and its use. There is high content of taurine in retina as the important factor of photoreceptor, and lack of taurine will result in the degradation and the optical conductance suppression of the photoreceptor. Shellfish meat contains rich amino acid, especially taurine, and trace elements and zinc, so that effective component is extracted from shellfish meat and prepared into eye medicine preparation. The pharmacological experiments show that the medicine of the present invention can treat cataract, eliminating eye fatigue, correct eyesight, resist inflammation, and treat acute and chronic conjunctivitis, ceratitis and other eye diseases.

Description

1. Technical field [0001] The invention relates to an ophthalmic medicament, especially an ophthalmic medicament prepared by extracting active ingredients from shellfish, and also relates to the use of the ophthalmic medicament. 2. Background technology [0002] Shellfish, including the soft tissues of Pteria martensii(Dunker)], Hyriopsis Cuningii(Lea)], Concha Meretrix Linnaen, and Ostrea Titan, are rich in amino acids Ingredients and other active ingredients, when people are studying its medicinal value, the specific efficacy of shellfish meat has gradually been proven. For example, the invention patent application with the publication number CN199050 discloses the preparation method of the amino polysaccharide of the pearl oyster shellfish, and discloses that the amino polysaccharide of the pearl oyster shellfish has the effects of invigorating the spleen and protecting the heart, promoting blood circulation and removing blood stasis, and can be used for hyperlipidemia S...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61K35/618A61P27/02A61P27/10A61P27/12
Inventor 沈祖陶邹贤刚梁祖珍
Owner 北海蓝海洋生物药业有限责任公司
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