Chitosan-containing polysaccharide, method for preparing the same and use thereof

Abstract

The present invention herein provides a chitosan-containing polysaccharide and a method for the preparation thereof as well as a medicine and a food containing the polysaccharide. The chitosan-containing polysaccharide is prepared by a method comprising the steps of heat-treating a fungus in a concentrated aqueous caustic alkali solution; subjecting the resulting solution to a solid-liquid separation treatment; dissolving the resulting solid contents in an aqueous organic acid solution; adding, to the resulting solution, an alcohol or a caustic alkali to thus form precipitates; washing the resulting precipitates; and then drying them. This chitosan-containing polysaccharide is a compound in which homopolymers of glucosamine are linked with glucan through covalent bonds; it has a molar ratio of glucosamine and glucose constituting the polysaccharide ranging from 1:5 to 5:1; it has a molecular weight of about 150,000; and it does not contain any beta (1->3) bonds, but comprises beta (1->4) bonds and beta (1->6) bonds. The polysaccharide is free of any protein and reducing polysaccharide. The chitosan-containing polysaccharide is effective for the treatment or prevention of any diseases originated from living habits or customs such as hypertension and diabetes.

Description

technical field [0001] The present invention relates to a novel chitosan-containing polysaccharide, a preparation method thereof, and a pharmaceutical composition and food containing the chitosan-containing polysaccharide as an active ingredient. Background technique [0002] So far, there have been a lot of studies on the properties and preparation methods of chitosan (hereinafter referred to as crab chitosan) of crustaceans such as crabs and shrimps, but about the plant chitosan represented by mushrooms. Polysaccharides and their preparation methods are rarely published in research literature. [0003] There have been some research reports on the chitosan produced by fungi such as Aspergillus niger, Saprolegnia, and actinomycetes. Chitosan cannot be used in foods, medicines, etc. that may cause safety problems to the human body. [0004] On the other hand, the hydrophilic solvent extract of the mushroom (Agaricus bisporus) known to be effective against kidney disease (tr...

AI Technical Summary

Problems solved by technology

[0012] However, at present, the skeleton components of mushrooms containing these chitins have good chemical stability and are insoluble in water, dilute acid or alkali, and organic solvents, so they are hardly used effectively.

One of the reasons is that chitin contained in mushrooms is insoluble in almost all solvents and has no physiological activity, so it cannot be expected to be effective in health food and medicine.