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Method for extracting high purity polysaccharide of membranous milk vetch and saponin of same

A technology of astragalus saponins and astragalus polysaccharides, which is applied in the field of high-purity astragalus polysaccharides, can solve the problems of low yield of crude polysaccharides and shortened reaction time, and achieve the effects of less product loss, shorter time and better appearance

Inactive Publication Date: 2005-12-21
甘肃祁连山生物科技开发有限责任公司
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Problems solved by technology

[0002] In recent years, there have been many research reports on the improvement and optimization of the process of extracting astragalus polysaccharides by boiling and alcohol precipitation: For example, in the Journal of Chinese Medicine. Extracting Astragalus polysaccharides can shorten the reaction time by about 12 times, and the polysaccharide content reaches 6.55%; Li Hongmin of Northwestern University et al. in the Journal of Northwestern University: Natural Science Edition. 2000.030 (006). The extraction method can significantly improve the polysaccharide yield, which is 11.7% and 5.7% respectively; Journal of Chinese Medicine. The optimization research on the boiling extraction process of Astragalus polysaccharides shows that the yield of crude polysaccharides of Astragalus membranaceus has obvious differences for different extraction times, the polysaccharide yield of the best process is 2.0%, and the total polysaccharide content is 37.5% (low temperature drying); Li Shuzhen from the Academy of Traditional Chinese Medicine compared the sugar content of crude polysaccharides obtained from different extraction processes of Radix Astragali in Chinese Herbal Medicine. 195.026(008).-408-410. The sugar content of the method is 20% higher, but the crude polysaccharide yield is lower; Feng Shilan et al. of Lanzhou Medical College also carried out orthogonal extraction process on the extraction process of astragalus polysaccharides in Chinese patent medicine 1997.12.25; 19 (12): 5-6 Experimental research, taking the content of astragalus polysaccharides as the evaluation standard, taking into account the indicators of water, ash, and insolubles in water, the results found that the content of astragalus polysaccharides is related to the concentration of ethanol in the process, the concentration of the medicinal solution and the drying method, and the specific gravity of the medicinal solution is determined to be 1.05 Precipitation with 80% ethanol and spray drying is the best process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Grind Astragalus membranaceus into granules, weigh 1 ton of Astragalus membranaceus granules, add 6 tons of mixed solvent, the mixed solvent is ethanol, water and n-butanol, ethanol: water: n-butanol=4:3:3; In the jacket of the tank, heat at 78°C to make the liquid medicine boil, and the solvent vapor generated during the extraction process is cooled by the top of the tank and then flows back into the extraction tank, extracted for 2 hours, filtered, and pumped out the extract A to the liquid storage tank middle; then add 6 times the amount of distilled water to the filtered medicinal dregs according to the weight ratio, pass the steam into the jacket of the tank, the temperature in the tank is 100°C, extract for 1.8 hours, filter, and pump out the extract B to In the liquid storage tank; combine the extracts A and B in the liquid storage tank; use the ultrafiltration method to obtain two products rich in astragalus polysaccharide and astragaloside respectively; combine ...

Embodiment 2

[0026] Crush the astragalus into granules, weigh it, and add 6 times the amount of mixed solvent. The mixed solvent is ethanol, water and n-butanol, ethanol: water: n-butanol=4:3:3; steam is passed into the jacket of the extraction tank, heated at 80°C to make the liquid boil, and the solvent vapor generated during the extraction process , after being cooled by the top of the tank, it flows back into the extraction tank, extracts for 2.2 hours, filters, and pumps out the extract A to the liquid storage tank; adds 6 times the amount of distilled water to the filtered medicinal residues by weight, and passes the steam Put it into the jacket of the tank, the temperature in the tank is 100°C, extract for 1.5 hours, filter, pump out the extract B to the liquid storage tank; combine the extracts A and B in the liquid storage tank; mix the mixed A, B extract solution, adopt ultrafiltration method, obtain two kinds of products rich in astragalus polysaccharide and astragaloside respec...

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Abstract

The invention belongs to the producing method of a kind of high purity radix astragali polysaccharide (RAPS) and astragalus saponin (AS). Its steps are: comminute radix astragali to granulated, after weighed, add six times quantities of mix solvent which is comprised of ethanol, water and n-butanol with proportion of 4 : 3 : 3; send gas into the pot, heat to boil the medicine fluid, circumfluence to distill, filtrate to get distilled liquid A; then add six times of distilled water as per weight proportion into filtrated medicine residue, steam heat to distill, filtrate to get distilled liquid B; mix distilled liquid A and B in liquid tank; then make the mixed A and B distilled liquid have twofold purification of ultra filtering - column chromatogram - solvent recrystallization, and ultra filtering - mellow sedimentation - solvent wash twofold purification method, to respectively get two kinds of products of high purity RAPS and AS. The products have good appearance, in industrial production, the distilling rate of RAPS and AS can respectively get to 94.5% and 92.3%, which are much higher than that of water distilling method and mellow distilling method reported in present literatures.

Description

technical field [0001] The invention belongs to a production method of high-purity astragalus polysaccharide and astragalus saponin. Background technique [0002] In recent years, there have been many research reports on the improvement and optimization of the process of extracting astragalus polysaccharides by boiling and alcohol precipitation: For example, in the Journal of Chinese Medicine. Extracting Astragalus polysaccharides can shorten the reaction time by about 12 times, and the polysaccharide content reaches 6.55%; Li Hongmin of Northwestern University et al. in the Journal of Northwestern University: Natural Science Edition. 2000.030 (006). The extraction method can significantly improve the polysaccharide yield, which is 11.7% and 5.7% respectively; Journal of Chinese Medicine. The optimization research on the boiling extraction process of Astragalus polysaccharides shows that the yield of crude polysaccharides of Astragalus membranaceus has obvious differences f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00
Inventor 赵光龙杨旭忠赵晓虎赵自丰
Owner 甘肃祁连山生物科技开发有限责任公司
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