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Composition of paeoniflorin and peony lactone glycoside with function of increasing leukocyte

A technology of paeoniflorin and paeoniflorin, which is applied in the field of medicine

Inactive Publication Date: 2011-11-16
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no uniform standard for the extract of Paeoniae Alba. The total glucosides of paeony capsules on the market are preparations made from the effective parts extracted from the traditional Chinese medicine Paeoniae Alba. It has pharmacological effects such as anti-inflammatory and immune regulation. Rheumatoid Arthritis Treatment

Method used

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  • Composition of paeoniflorin and peony lactone glycoside with function of increasing leukocyte
  • Composition of paeoniflorin and peony lactone glycoside with function of increasing leukocyte
  • Composition of paeoniflorin and peony lactone glycoside with function of increasing leukocyte

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Embodiment

[0055] 1. Dried Paeoniae Alba Radix slices 10Kg, boiled with water to extract twice, each time for 2 hours, the extract was filtered and passed through a reverse adsorption resin column, and then eluted with alcohol water, the eluent was concentrated and then chromatographed on a silica gel column to obtain The extract rich in paeoniflorin and paeonifloride components was finally decolorized by activated carbon, filtered, and the filtrate was concentrated under reduced pressure and dried in vacuum to obtain 150 g of the composition described in this patent (hereinafter referred to as the composition).

[0056] 2. 50g of this composition is mixed with 45g of microcrystalline cellulose and 5g of magnesium stearate, and the mixture is used for tableting. Each tablet weighs 0.2g, and each tablet contains 0.1g of this composition. According to the symptoms, take 1-2 tablets each time, 2-3 times a day.

[0057] 3. Combine 50g of this composition with 50g of cornstarch, add water to ...

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Abstract

The present invention relates to a composition containing the active components of paeoniflorin and albiflorin extracted and seperated from Paeonia lactifora Pall, the total content of the two components being between 50% and 95 % and weight ratio of the paeoniflorin and albiflorin in the composition being 1:10-10:1. The composition is applicable for preparing various simple prescription medicine preparations, delayed releasing preparation or controlled releasing preparation, preparation by body cavity administration, spray administration, transdermal absorption or oral administration; injection preparation or transfused fluid preparation; or for combining with other medicine (containing Chinese traditional medicine extract or effective component) to form compound medicine preparation by replacing peony extract or peony total glycosides. The composition is suitable for preparing medicine for treating leucopenia, throbocytopenia and achreocythemia of different causes.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically, it is a composition of paeoniflorin and paeoniflorin which has the effect of raising white blood cells. Background technique: [0002] Paeoniae Alba is the dried root of the perennial herbaceous plant Paeoniae officinalis of the Paeoniaceae Paeoniaceae family. The so-called Radix Paeoniae Alba and Radix Paeoniae Rubra, according to the current application situation and the records in the herbal medicine of past dynasties, it can be considered that Radix Paeoniae Alba is the root of cultivated Radix Paeoniae Alba, and Radix Radix Radix Radix Rubrae mainly comes from the roots of wild Radix Paeoniae. Peony is distributed in the northern part of my country, and another grass peony P.obovata.Maxim. of the same genus is distributed in Northeast, North, Central, Southwest and other regions. Sichuan red peony P.veitchiiLynch. distribution in Gansu, Shanxi, Sichuan, Tibet and other provi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P35/00
Inventor 游松郭丽清孙燕王慧敏曹颖林曹雅明
Owner SHENYANG PHARMA UNIVERSITY
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