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Combination of treating and/or preventing hemorrhoid

A kind of composition, the technology of medicine, be used in the field of combination therapy for the treatment of hemorrhoids, and the field of pharmaceutical compositions for the treatment and/or prevention of hemorrhoids

Inactive Publication Date: 2005-08-31
BEIJING BIOSIS HEALING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no literature report on the use of NOS inhibitors for the treatment of hemorrhoids and the preparation of drugs for the treatment of hemorrhoids

Method used

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  • Combination of treating and/or preventing hemorrhoid
  • Combination of treating and/or preventing hemorrhoid
  • Combination of treating and/or preventing hemorrhoid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1: Differences in MVD and elastic fibers between hemorrhoid tissue and relatively normal anal cushion tissue, as well as the expression and difference of NOS, PDE5, VEGF, MMP1, 3, 9, and 12

[0094] 1. Materials and methods

[0095] Selected 24 cases of suprahemorrhoidal mucosal circumcision and stapling (PPH surgery) specimens obtained from October 2003 to August 2004, mainly selecting one or two female hemorrhoids among the three female hemorrhoids with obvious lesions, but at least one female hemorrhoid Internal hemorrhoid specimens from patients with grade III hemorrhoids with inconspicuous "hemorrhoids" lesions. The patients were aged between 35-60. After PPH operation, the protruding female hemorrhoid tissue and relatively normal anal cushion tissue were fixed in 15% neutral formalin solution, embedded in paraffin, and serially sectioned.

[0096] Paraffin sections of all patients were stained by H.E and immunohistochemical streptavidin-biophilin-peroxid...

Embodiment 2

[0116] Example 2: Preparation of Suppository A Containing At Least One Nitric Oxide Synthase Inhibitor At Least One Angiogenesis Inhibitor And At Least One Matrix Metalloproteinase Inhibitor

[0117] With conventional suppository preparation method, the following compounds are mixed in the content ratio described in the table (table 2):

[0118]

ingredient name

in each suppository

content of ingredients

Features

activity

Element

Aminoguanidine

10mg

NOS inhibitor

Fangchinoline

10mg

VEGF inhibitor

Rosiglitazone

1mg

MMP inhibitor

That

he

become

Minute

Polyoxyethylene glycol palmitate

Fatty acid ester

160mg

Self-emulsifying fat base

Saturated Polysaccharide Glycerides

120mg

fat soluble carrier

Dimethicone

320mg

liquid solvent

Hydrophobic hydroxypropyl methylcellulose

...

Embodiment 3

[0121] Example 3: Preparation of Suppository B Containing At Least One Nitric Oxide Synthase Inhibitor At Least One Angiogenesis Inhibitor And At Least One Matrix Metalloproteinase Inhibitor

[0122] With conventional suppository preparation method, the following compounds are mixed according to the content ratio described in the table (table 3):

[0123]

ingredient name

in each suppository

content of ingredients

Features

live

sex

become

Minute

COL-3

10mg

MMP inhibitor

N-monomethyl-L-arginine

sour

10mg

NOS inhibitor

triacetin acetic acid

10mg

VEGF inhibitors

That

he

become

Minute

Polyoxyethylene glycol palmitate

Fatty acid ester

160mg

Self-emulsifying fat base

Saturated Polysaccharide Glycerides

120mg

fat soluble carrier

Dimethicone

320mg

liquid...

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PUM

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Abstract

A composition for preventing and / or treating piles contains at least one NO synthetase (NOS) inhibitor, especially iNOS inhibitor, at least one vascular angiogenesis inhibitor, especially VEGF inhibitor, and at least one matrix metal proteinase (MMP) inhibitor, especially MMP1, MMP3, MMP9 and / or MMP12 inhibitor.

Description

Technical field: [0001] The present invention relates to the preparation of a pharmaceutical composition for treating and / preventing hemorrhoids. The pharmaceutical composition comprises at least one nitric oxide synthase inhibitor, at least one angiogenesis inhibitor and at least one matrix metalloproteinase inhibitor. The pharmaceutical composition can be suppository, ointment, cream, fumigant, lozenge, tablet, pill, capsule, powder, granule, injection and / or oral liquid, preferably suppository. The present invention also relates to a combination therapy for the treatment of hemorrhoids comprising the combined administration of nitric oxide synthase inhibitors, angiogenesis inhibitors and matrix metalloproteinase inhibitors. Background of the invention: [0002] Hemorrhoids are the pathological changes and (or) abnormal displacement of the supporting structure of the anal cushion (anal canal vascular cushion), vascular plexus and arteriovenous anastomotic branches, which ...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61P9/14
Inventor 王振军赵博韩炜
Owner BEIJING BIOSIS HEALING BIOLOGICAL TECH
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