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Povidone iodine toothpaste and preparing method

A technology of povidone-iodine and toothpaste, which is applied in the field of toothpaste preparation and can solve the problems of short stagnation time and impact

Active Publication Date: 2005-06-15
GUANGDONG KELUN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gargling with 1% povidone-iodine solution has a certain effect on inhibiting the formation of dental plaque and preventing oral infections such as periodontal disease and dental caries, but the effect of the solution is affected due to the short stagnation time of the solution in the oral cavity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation method of the present invention: (1) take 1 kilogram of sodium carboxymethylcellulose and add 28 kilograms of glycerin, swell and disperse, and place for 12 hours; (2) get 0.8 kilogram of sodium alginate and add 5 kilograms of purified water to dissolve; (3) put (1), (2) After the liquids are mixed, add 15 kilograms of sorbitol, and stir until there is no particle of transparent glue; (4) get 2.5 kilograms of sodium lauryl sulfate and 0.02 kilograms of potassium iodate plus 28.08 kilograms of purified water, put Heat and dissolve in a water bath, let cool, add 1 kg of povidone iodine and 0.1 kg of sodium saccharin and stir to dissolve; (5) add (4) solution into (3), stir evenly, add 18 kg of silicon dioxide, Stir evenly; (6) get 0.5 kg of peppermint oil and dissolve it in 1000 ml of ethanol with a concentration of 95%, add it to (5), stir evenly, and adjust the pH to 5.0 with sodium dihydrogen phosphate buffer to obtain povidone-iodine toothpaste 100 kg....

Embodiment 2

[0024] The preparation method of the present invention: (1) take 1.5 kilograms of sodium carboxymethyl cellulose and add 30 kilograms of glycerin, swell and disperse, and place for 16 hours; (2) take 1 kilogram of sodium alginate and add 5.32 kilograms of purified water to dissolve; (3) ( 1), (2) After the liquids are mixed, add 13 kilograms of sorbitol, and stir until it becomes a transparent glue without particles; (4) Take 3 kilograms of sodium lauryl sulfate and 0.03 kilograms of potassium iodate plus 24 kilograms of purified water, and place Heat and dissolve in a water bath, let cool, add 1 kg of povidone iodine and 0.15 kg of sodium saccharin and stir to dissolve; (5) add (4) solution into (3), stir evenly, add 20 kg of silicon dioxide, Stir evenly; (6) get 1 kilogram of peppermint oil and dissolve it in 1200 milliliters of ethanol with a concentration of 95%, add it to (5), stir evenly, and adjust the pH to 6.5 with disodium hydrogen phosphate buffer to obtain povidone-...

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PUM

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Abstract

A povidone iodine toothpaste for preventing and treating dental plaque is prepared through dissolving carboxymethyl cellulose sodium in glycerin, dissolving sodium alginate in purified water, mixing them together, adding sorbitol, stirring to obtain solution A, adding sodium laurylsulfate and potassuim iodate to purified water, heating, adding povidone iodine and sodium saccharin, stirring, mixing it with solution A, adding SiO2, stirring to obtain mixture B, dissolving mint oil in alcohol, adding it to mixture B, and using the solution of sodium dihydrogen phosphate or bisodium hydrogen phosphate to regulate pH=5.5-6.5.

Description

technical field [0001] The invention relates to a preparation method of toothpaste, in particular to a preparation method of toothpaste containing povidone-iodine. Background technique [0002] Dental plaque is an important cause of dental caries and periodontitis, two major oral diseases in humans. It is not easy to be removed because it is insoluble in water, has a certain degree of viscosity, and has good adhesion, and the formation of plaque is related to bacterial infection. There are many methods currently used to control plaque, such as mechanical methods and drug methods. Antibacterial or bactericidal ingredients such as chlorhexidine are added to toothpaste, and the most popular bactericide in the world is Yujiechun, all of which have a certain inhibitory effect on the flora. However, chlorhexidine has a bitter taste and is ineffective against infections caused by acid bacilli, fungi, and viruses; Yujiechun uses enol polymers and Chinese herbal medicine components...

Claims

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Application Information

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IPC IPC(8): A61K9/16
Inventor 张京维熊国运
Owner GUANGDONG KELUN PHARMACEUTICAL CO LTD
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