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Preparation technology of globe fish peptide and its medical health care use

A technology of puffer fish and puffer fish skin is applied in food preparation, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as side effects, physical and psychological damage of patients, etc.

Inactive Publication Date: 2005-03-09
NANJING BESSON PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0042] One of the biggest problems of clinical chemotherapy is the side effects after chemotherapy, which often cause huge physical and psychological harm to patients, which sometimes even exceeds the harm caused by the tumor itself

Method used

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  • Preparation technology of globe fish peptide and its medical health care use
  • Preparation technology of globe fish peptide and its medical health care use
  • Preparation technology of globe fish peptide and its medical health care use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] Example 1: Get 100 grams of puffer fish skin, add 250 ml of deionized water, heat and extract at 100 ° C for 8 hours, homogenate, after the homogenate is filtered, the filtrate is vacuum concentrated to 150 ml, and the air is discharged at a temperature of 260 ° C. Spray-dry at a temperature of 125°C to obtain light yellow pufferfish peptide dry powder.

[0142] Take an appropriate amount of the pufferfish peptide dry powder and use 6N hydrochloric acid to seal and hydrolyze it at 110°C for 24 hours, measure the content of hydroxyproline according to the Kivirikko method and calculate the collagen content, and the result shows that the collagen content of the pufferfish peptide is 83%.

Embodiment 2

[0143]Example 2: Take 500 grams of puffer fish bones (fins), add 1500 ml of deionized water, heat and extract at 100° C. for 10 hours, filter, concentrate the filtrate in vacuum to 250 ml, and spray dry to obtain light yellow puffer fish peptide dry powder.

[0144] As determined by the Kivirikko method, the result shows that the collagen content of the pufferfish peptide is 48%.

Embodiment 3

[0145] Example 3: Get 500 grams of puffer fish bones (fins), add 1500 ml of deionized water, heat and extract at 100 ° C for 4 hours, filter, and use the filtrate for later use, add 1500 ml of water to the filter residue for the same extraction, repeat the extraction for 5 times, and combine all The filtrate, the filtrate was concentrated in vacuum to 250ml, spray-dried under the conditions of 280°C air inlet and 145°C air outlet to obtain light yellow pufferfish peptide dry powder.

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Abstract

A process for preparing tetrodopeptide from the skin and / or bone of globefish includes pretreating, extracting, concentrating, drying and pulverizing. Said tetrodopeptide can be used to prepare medicines or health-care food for preventing and treating the diseases in digestive system, immunopathy and tumor.

Description

technical field [0001] The invention belongs to the fields of traditional Chinese medicines, biochemical medicines and health care products. Specifically, the present invention relates to puffer fish skin and / or fish bone (fin) protein polypeptide products— puffer fish with puffer fish collagen or its denatured collagen and their mixture and partial hydrolyzate as the main chemical and active ingredients Peptide, preparation process of pufferfish peptide, immunological assay method of pufferfish peptide and use of pufferfish peptide as active ingredient in medicine and health food. Background technique [0002] Notes on puffer fish and puffer fish: [0003] According to fish taxonomy, the term "puffer fish" is an aquatic mammal belonging to the order Cetacea and the family Platanistidae; , the evolutionary stages of the two are very different, and they belong to different classes and orders. Therefore, they are two completely different types of fish, and the puffer fish u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61K38/39A61P1/00A61P1/04A61P1/16A61P17/00A61P19/02A61P25/32A61P35/00A61P37/02C07K14/78C12P21/00
CPCA23L1/05625A61K38/39A23L29/284A61P1/00A61P1/04A61P1/12A61P1/14A61P1/16A61P9/04A61P13/12A61P17/00A61P19/02A61P25/02A61P25/32A61P29/00A61P35/00A61P35/02A61P35/04A61P37/02A61P37/04
Inventor 陈丁丁高利忠
Owner NANJING BESSON PHARMACY
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