Fine stitch array for medicine controlled releasing

A technology of microneedle array and drug controlled release, applied in the field of drug controlled release microneedle array, can solve the problems of easily causing infection and pain, and achieve the effect of reducing the probability of infection, sharp needles, and reducing the degree of damage

Inactive Publication Date: 2004-11-03
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the traditional injection, the needle must penetrate the skin and enter the deep tissue to effectively deliver the drug, but it is easy to cause infection and pain, especially for some drugs that should not be taken orally, the dosage is small, and require frequent injections, the traditional injection is more and more popular. the more it shows its limitations

Method used

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  • Fine stitch array for medicine controlled releasing
  • Fine stitch array for medicine controlled releasing
  • Fine stitch array for medicine controlled releasing

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0015] Such as figure 1 , figure 2 Shown, the present invention it comprises:

[0016] A microneedle array consisting of a group of equidistantly distributed conical hollow microneedles 1 is formed on the substrate 2 with grooves 4 on the bottom surface. The pinholes of the microneedles are on one side of the needle head, and the microneedle pinholes are connected to the grooves 4 on the bottom surface of the substrate. Pass.

[0017] The length L of the conical hollow microneedle 1 is 100-150 μm, the outer diameter D of the cone bottom is 50-80 μm, the inner diameter d of the microneedle pinhole is 10-40 μm, and the pinhole length 1 of the microneedle is 80-100 μm, The spacing S between one microneedle is 100 to 120 μm.

[0018] The present invention is used for the processing method of a kind of microneedle array of drug controlled release:

[0019] 1) Oxidize the silicon wafer to form a layer of silicon dioxide oxide film, then clean and dry the silicon wafer;

[0020...

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Abstract

The mini needle array for controlling release of medicine includes one base board with slot in the bottom and one array of homogeneously distributed conic hollow mini needles, each of which is provided with eccentric hole in the tip and communicated with the slot in the base board. The mini needle array is manufactured via DIRE technological process to etch silicon. It is used for injection and has great hole depth / width ratio, sharp needle tip, moderate length, less destruction to skin, high medicine conveying efficiency, no pain produced and low infection probability.

Description

Technical field [0001] The invention relates to a drug controlled release device, in particular to a microneedle array for drug controlled release. Background technique [0002] The main obstacle to drug transdermal absorption comes from the stratum corneum of human skin, which is about 10-15 μm thick. In the traditional injection, the needle must penetrate the skin and enter the deep tissue to effectively deliver the drug, but it is easy to cause infection and pain, especially for some drugs that should not be taken orally, the dosage is small, and require frequent injections, the traditional injection is more and more popular. The more it shows its limitations. How to efficiently, accurately, and painlessly deliver drugs into the human body has become a hot research topic at home and abroad in recent years. Microneedle is one of the research hotspots. The processing of microneedles is based on MEMS micromachining technology, using crystalline silicon, polymers, metals, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M35/00
Inventor 傅新谢海波焦峰
Owner ZHEJIANG UNIV
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