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Process based on fast shaping for preparing bio-active artificial bone

A technology of biological activity and manufacturing method, applied in the direction of bone implants, medical science, prosthesis, etc., can solve the problems of limiting the scope of use, not suitable for infiltration, long time, etc.

Inactive Publication Date: 2002-09-11
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it takes a long time for bone growth factor cells to enter the artificial bone, and it is not suitable for infiltration, which limits its application range.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Bionic CAD design of artificial bone: CAD design of bone shape, through CT characteristic cross-section measurement or external surface measurement, use characteristic data points to reconstruct the three-dimensional CAD of bone shape, and express it in STL data format; For three-dimensional CAD design, if based on CT section data, the CAD of the bone marrow cavity can be constructed by reconstruction method; if based on the measurement data of the outer surface, a mathematical model can be established by using the shape of the outer surface to construct the CAD of the bone marrow cavity; the CAD of skeletal bone tissue Design, observe the size and distribution of bone micropores through an electron microscope, establish a mathematical model of bone tissue microstructure, construct a three-dimensional CAD of the bone, and ensure the complete conduction of the micropore space; through the above three parts of the bionic CAD modeling design, the Combining external CAD a...

Embodiment 2

[0033] 1. Bionic CAD design of artificial bone: CAD design of bone shape, through CT characteristic cross-section measurement or external surface measurement, use characteristic data points to reconstruct the three-dimensional CAD of bone shape, and express it in STL data format; For 3D CAD design, if based on CT section data, the CAD of bone marrow cavity can be constructed by reconstruction method; if it is based on the measurement data of the outer surface, a mathematical model can be established by using the shape of the outer surface to construct the CAD of the bone marrow cavity; the CAD of skeletal bone tissue Design, observe the size and distribution of bone micropores through an electron microscope, establish a mathematical model of bone tissue microstructure, construct a three-dimensional CAD of the bone, and ensure the complete conduction of the micropore space; through the above three parts of the bionic CAD modeling design, the Combining external CAD and internal C...

Embodiment 3

[0039] 1. Bionic CAD design of artificial bone: CAD design of bone shape, through CT characteristic cross-section measurement or external surface measurement, use characteristic data points to reconstruct the three-dimensional CAD of bone shape, and express it in STL data format; For three-dimensional CAD design, if based on CT section data, the CAD of the bone marrow cavity can be constructed by reconstruction method; if based on the measurement data of the outer surface, a mathematical model can be established by using the shape of the outer surface to construct the CAD of the bone marrow cavity; the CAD of skeletal bone tissue Design, observe the size and distribution of bone micropores through an electron microscope, establish a mathematical model of bone tissue microstructure, construct a three-dimensional CAD of the bone, and ensure the complete conduction of the micropore space; through the above three parts of the bionic CAD modeling design, the Combining external CAD a...

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Abstract

A process based on fast shaping technique for preparing biological active artificial bone includes such steps as creating CAD 3D internal microstructure and external shape model of bone by CT data, fast shaping the microstructure and the negative mould of its external shape, implantating biological factors or cells, adding Ti fibres for reinforcing mechanism property, filling biological bone material, and preparing artificial substitute bone. Its advantages are high individual adaptibility, high preparing speed good biological compatibilility and high survival rate after implanlation.

Description

1. Technical field [0001] The invention belongs to the medical restoration engineering in the manufacturing field, and in particular relates to a composite manufacturing method based on rapid prototyping of artificial bioactive bones. 2. Background technology [0002] Various reasons such as diseases, accidents and wars have caused a large number of human traumas, and the damage to human bones has caused many people to become disabled and lose their basic living capabilities. This has brought great impact to the patient's family and society. How to help patients repair defective or missing hard tissues and better restore the functions of human hard tissues is a problem that the medical community has been exploring. From the perspective of biocompatibility, it is ideal to take the same kind of tissue from the patient as the material for repairing damaged tissue, but this not only increases the chance of infection, but also limits the bone source. Using allogeneic bone (anim...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/00
Inventor 李涤尘卢秉恒吴永辉
Owner XI AN JIAOTONG UNIV
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