Sulfamethoxazole decoloring and refining process with sulfur dioxide and carbamide

A technology of thiourea dioxide and sulfamethoxazole, applied in the direction of organic chemistry, etc., can solve the problems of low sulfamethoxazole specification, lack of competitive advantage, backward decolorization and refining process, etc.

Inactive Publication Date: 2002-07-10
昆山虹祺药业有限责任公司
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  • Summary
  • Abstract
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Problems solved by technology

[0003] The present invention aims to solve the problem that the produced sulfamethoxazole has low specifications and lacks competitive advantages due to the backwardness of the current decolorization and refining process.

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment

[0005] Example: In the decolorization pot, add 200 kg of sulfamethoxazole crude product, add 1000 kg of pure water, gradually increase the temperature, add 30 kg of activated carbon, raise the temperature to 85±5°C, keep the temperature for 0.5 to 1 hour for decolorization, and then put the mother liquor while it is hot Filtrate, press filter mother liquor into the crystallization pot, add charcoal washing water to the decolorization at the same time, after heating to 85-90°C, press filter, wash charcoal in stages, and press dry. Heat the filtrate to 85±1°C, add 0.6 kg of thiourea dioxide, acidify with dilute hydrochloric acid, measure the pH value with precision test paper between 4.1 and 4.6, keep unchanged for ten minutes, raise the temperature to 90±2°C, cool to 25°C, Keep the temperature and PH value constant for a period of time (as the PH value increases, it is necessary to continuously retest and add hydrochloric acid to 25 degrees Celsius to keep the PH value constant)...

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Abstract

The present invnetion is sulfamethoxazole decoloring and refining process with sulfur dioxide and carbamide and aims at improving the quality of sulfamethoxazole as one kind of sulfonamide. The technological scheme includes: predecoloring of coarse sulfamethoxazole after mixing with pure water and with active carbon at 85-90 deg.c; press filtering, washing to eliminate carbon, decoloring filtrate liquid with sulfur dioxide and carbamide, acid separation with dilute hydrochloric acid in certain pH value; and cooling, discharge, spinning drying to neutral, and drying to obtain refined sulfamethoxazole. The present invention has the advantages of less material consumption and high quality of the refined product.

Description

(1) Technical field [0001] The invention relates to a process for decolorizing and refining sulfamethoxazole. (2) Background technology [0002] Sulfamethoxazole is a kind of sulfonamide drug. It is compatible with antibacterial synergist (TMP) to form compound sulfamethoxazole. This medicine has the advantages of wide antibacterial spectrum, definite curative effect, and low toxic and side effects. It is a bulk drug in clinical use at present, but Due to the backwardness of the traditional decolorization and refining process, the produced sulfamethoxazole has low specifications and lacks competitive advantages. (3) Contents of the invention [0003] The present invention aims to solve the problem that the produced sulfamethoxazole has low specifications and lacks competitive advantages due to the backward decolorization and refining process at present. The technical scheme adopted is: a process of decolorizing and refining sulfamethoxazole with thiourea dioxide, which is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D261/14
Inventor 潘雪龙王皆胜
Owner 昆山虹祺药业有限责任公司
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