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Smoking products containing antioxidants

A technology of tobacco and snuff, applied in the direction of medical preparations containing active ingredients, products for smokers, compositions for inhibiting chemical changes, etc., which can solve the problems of increased morbidity, increased DNA damage in cells, etc.

Inactive Publication Date: 2002-03-06
THIONE INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has also been shown that cells subjected to ionizing radiation and cigarette smoke have increased intracellular DNA damage and, consequently, increased incidence of oropharyngeal, esophageal, and lung cancers in smokers

Method used

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Embodiment Construction

[0015] Without being bound by any particular theory, we have found that reduced glutathione protects cells from oxidative stress by oxidizing itself. Therefore, L-glutathione must function in combination with other enzyme systems in order to be reduced and resume its role as a free radical scavenger. GSH also cooperates with glutathione peroxidase, which needs selenium as a cofactor, to exert its function as a biological antioxidant. Selenium compounds are known to be able to scavenge oxygen-centered free radicals in the body together with reduced glutathione through the action of glutathione peroxidase. Selenium-GSH peroxidase is believed to catalyze toxic hydroperoxidase in the presence of reduced glutathione. This reaction reduces glutathione to generate oxidized glutathione GSSG. GSSG is then reduced to GSH by glutathione reductase, thereby maintaining sufficient cellular GSH to rescavenge free radicals.

[0016] In addition, glutathione and selenium have a synergistic ...

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Abstract

A composition for inclusion within a quantity of smokeless tobacco. The composition of antioxidants is capable of reducing free radical damage to the oro-pharyngeal cavity of a user resulting from consumption of smokeless tobacco. The composition includes L-glutathione and a source of selenium.

Description

field of invention [0001] The present invention relates to combinations of synergistic antioxidants, enzymatic cofactors such as selenium-containing compounds, and amino acids in suitable delivery vehicles for use in so-called "smokeless tobacco" as a means of preventing or mitigating the effects of these products. Means signs and symptoms and complications caused by injury to the oropharyngeal cavity. Background of the invention [0002] Tobacco is a substance composed of the dried leaves of the plant Nicotiana tabacum, which contains the addictive drug nicotine. The plant is native to North America, but is now grown throughout the world. Tobacco abuse is recognized as the most preventable cause of disease, morbidity and death. Tobacco contains and produces many toxic chemicals and free radicals. Tobacco is smoked in 3 main ways: 1) smoking; 2) chewing and leaching, and 3) snorting. 50,000,000 Americans smoke, and countless others are affected by tobacco smoke, so-calle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24B13/00A24B15/16A24B15/14A24B15/30A24B15/32A24B15/42A24D1/00A24D1/02A24D3/14A24D3/16A61K9/72A61K31/07A61K31/198A61K31/355A61K31/375A61P11/00A61P11/04C09K15/28D21H27/00
CPCA24D3/16A24B15/301A24B15/32A24B15/42A24B15/16A24D3/14A24B15/308A24D1/002Y10S514/959A61P11/00A61P11/04
Inventor T·赫什R·赫什
Owner THIONE INT
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