Method for coding and identifying resin microsphere by infrared spectrum

Abstract

The invention p discloses a method for coding and recognizing resin microsphere by infrared spectrum, including the steps of: 1. building a characteristic bar code base for polystyrene resin microsphere; 2.converting the infrared spectrum of resin microsphere to be identified into bar code, according to the same converting rule; 3. comparing the bar code to be identified with the characteristic bar codes in the said base, one after another, and using the percentage to represent the number of the same-positioned bars of the bar code to be identified and some characteristic bar code: if the percentage is greater than the specified value N, it is shown that the identified resin microsphere contains the polystyrene or component of its same-system substance corresponding to the characteristic bar code. The method converts peak position, strength and half-peak width, related with molecular structure, in the infrared spectrum of resin microphere, into bar code, so as to make fast auto recognition on polystyrene resin microphere, simple and easy to apply, and particularly helpful to implement a high flux drug screening system.

Description

technical field [0001] The invention belongs to the technical fields of molecular spectroscopy and medicinal chemistry, and specifically relates to a method for spectrally encoding and identifying polystyrene resin microspheres by using infrared spectroscopy, and is especially suitable for a new type of self-encoding spectral identification high-throughput drug screening system accomplish. Background technique [0002] As a recent precoding strategy, spectral coding is applied to the coding of resin microspheres. It can not only monitor the solid-phase synthesis reaction, but also be used for the synthesis of target molecules. It can be widely used in the synthesis and screening of compound libraries, high-pass Quantitative drug screening, biomedical diagnosis and so on. [0003] In a high-throughput drug screening system based on vibrational spectrum-encoded microspheres, the infrared or Raman spectra of different microspheres used as carriers are generally measured first,...

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Problems solved by technology

However, the Fenniri research team did not make a detailed description of the specific coding principles and identification standards. In addition, the research work of the group did not consider the impact of impurities and other factors on the coding, which greatly reduced the accuracy of identification, thus to a certain extent This hinders the application of this method to self-encoded spectral recognition for high-throughput drug screening

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