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Method for preparing compound licorice buccal tablet

A technology of compound licorice and preparation steps, which is applied in the field of preparation of compound licorice buccal tablets, which can solve problems affecting product quality, color, poor taste, and easy moisture absorption of the product, so as to improve the problem of moisture absorption, taste and moisture absorption Problems, therapeutic enhancement effects

Inactive Publication Date: 2006-10-25
GANDI PHARM MFG GANSU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to the active ingredient glycyrrhizic acid, the licorice extract powder also contains a large amount of invalid macromolecular impurities. The existence of these invalid ingredients causes the product to absorb moisture easily, has poor color and taste, and affects product quality.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation Example 1 Tablet Preparation

[0032] Formula 1: Licorice Extract Powder 112.5g Star Anise Oil 2g

[0033] Opium Powder 4g Sodium Benzoate 2g

[0034] Camphor 2g Beta-cyclodextrin 32g

[0035] borneol 2g citric acid 10.5g

[0036] Sucrose 246g Lactose 164g

[0037] Talc 4g Fragrance 2g

[0038] A total of 1000 pieces were made

[0039] Preparation:

[0040] 1) Add licorice extract powder with water with a weight / volume ratio of 1:4 times, heat and stir to dissolve, cool to 24°C, slowly add licorice extract powder and dilute hydrochloric acid in a weight / volume ratio of The concentration of 1:0.5 is 1% dilute hydrochloric acid, continue to stir for 10 minutes, let it stand for 1.5 hours, filter, add licorice extract powder and dilute ammonia water in the weight / volume ratio of 1:0.4, and the concentration is 0.6% The dilute ammonia water is heated and stirred to dissolve, concentrated into a thick paste, ...

Embodiment 2

[0043] Formulation Example 2 Preparation of Tablets

[0044] Formula 2: Licorice Extract Powder 112.5g Star Anise Oil 2g

[0045] Opium Powder 4g Sodium Benzoate 2g

[0046] Camphor 2g - Cyclodextrin 32g

[0047] Sucrose 282g Lactose 188g

[0048] Citric Acid 12g Menthol 2g

[0049] Magnesium Stearate 4g Flavor 2g

[0050] A total of 1000 pieces were made

[0051] Preparation:

[0052] 1) Add licorice extract powder with water with a weight / volume ratio of 1:10 times, heat and stir to dissolve, cool to 20°C, slowly add licorice extract powder and dilute hydrochloric acid in a weight / volume ratio of The concentration of 1:3.2 is 10% dilute hydrochloric acid, continue to stir for 50 minutes, let stand for 20 hours, filter, add licorice extract powder and dilute ammonia water in the weight / volume ratio of 1:3.2, and the concentration is 10.5% The dilute ammonia water is heated and stirred to dissolve, concentrated into a thick pas...

Embodiment 3

[0055] Formulation Example 3 Preparation of Tablets

[0056] Recipe 3: licorice extract powder 112.5g star anise oil 2g

[0057] Opium Powder 4g Sodium Benzoate 2g

[0058] Camphor 2g Beta-cyclodextrin 32g

[0059] Mannitol 300g Microcrystalline Cellulose 188g

[0060] Pectin 20g Aspartame 5g

[0061] Talc 4g Fragrance 2g

[0062] A total of 1000 pieces were made

[0063] Preparation:

[0064] 1) Add licorice extract powder to water with a weight / volume ratio of 1:6 times, heat and stir to dissolve, cool to 25°C, slowly add licorice extract powder and dilute hydrochloric acid in a weight / volume ratio of 1: The concentration of 0.8 is 2.6% dilute hydrochloric acid, continue to stir for 30 minutes, let stand for 3 hours, filter, add licorice extract powder and dilute ammonia water in the weight / volume ratio of 1: 0.8, and the concentration is 2% The dilute ammonia water is heated and stirred to dissolve, concentrated into a th...

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PUM

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Abstract

The invention discloses a preparation method of compound licorice buccal tablets, which comprises the following steps: 1) purifying licorice extract powder; 2) encapsulating camphor and star anise oil; 3) encapsulating plain tablets film coating. The product processed through the above steps has a good taste when taken orally, overcomes the so-called "first-pass effect" of the liver, improves bioavailability and product stability, and has rapid action and obviously enhanced curative effect.

Description

【Technical field】 [0001] The invention relates to a preparation method of compound licorice buccal tablets. 【Background technique】 [0002] Compound Licorice Tablets is a compound preparation made by mixing licorice extract powder, opium powder, star anise oil, camphor and sodium benzoate. The clinical usage is oral or buccal, but when most clinicians use the drug, they prescribe it orally, and the curative effect is not good. [0003] Licorice extract powder is one of the components of compound licorice tablets. Its main active ingredient is glycyrrhizic acid, which belongs to the nerve ending cough medicine. It achieves antitussive effect by covering the inflamed throat mucosa to reduce irritation. The active ingredient glycyrrhizic acid was released slowly in the oral cavity and directly acted on the throat to exert curative effect when taken buccally; glycyrrhizic acid could not directly act on the throat when taken orally, thus reducing the expectorant and antitussive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57A61K36/484A61K31/125A61K9/20A61K9/28A61P11/10A61P11/14A61K125/00
Inventor 辛占昌
Owner GANDI PHARM MFG GANSU
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