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Bee glue flavone extract preparation method, pharmaceutical preparation and its new medical uses

A technology of propolis flavonoids and extracts, which can be applied in directions such as drug combination, drug delivery, and pharmaceutical formulation, and can solve problems such as no reports.

Inactive Publication Date: 2006-09-13
CHANGCHUNG COLLEGE OF TRADITIONAL CHINESE MEDIICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no report about methods such as propolis flavonoid treatment coronary heart disease, angina pectoris, hyperlipidemia before the present invention is accomplished

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Take the propolis medicinal material, freeze (-10°C-4°C) for 5 hours, crush it into a coarse powder, add 95% ethanol to extract twice at a ratio of 20ml per gram of propolis, each time for 24 hours, filter, combine the filtrate, reduce The solvent was recovered under pressure, concentrated into a thick paste, dried under reduced pressure at 80°C and 0.05Mpa, and crushed into fine powder. Add 100ml of chloroform-ethanol (10:1-3:1) per gram of dry powder to dissolve, extract twice with an equal volume of 5% sodium hydroxide solution, add hydrochloric acid to the alkaline extract to adjust the pH to 4-8, produce precipitation, and let it stand for 24 hour, filter with suction, wash with water until neutral, dry under reduced pressure at 60°C and 0.05Mpa, and pulverize into fine powder to obtain the propolis flavonoid extract of the present invention.

Embodiment 2

[0051] Take the propolis medicinal material, freeze (-10°C-4°C) for 5 hours, crush it into coarse powder, extract twice with 65% ethanol at a ratio of 10ml per gram of propolis, 10 hours each time, filter, combine the filtrates, and recover under reduced pressure The solvent is concentrated into a thick paste, dried under reduced pressure at 55°C and 0.05Mpa, and crushed into fine powder. Add 200ml of chloroform-ethanol (10:1-3:1) per gram of dry powder to dissolve, extract twice with an equal volume of 1.5% sodium hydroxide solution, add hydrochloric acid to the alkaline extract to adjust the pH to 4-8, produce precipitation, and let stand for 24 hour, filter with suction, wash with water until neutral, dry under reduced pressure (40°C-80°C, 0.05MPa), and pulverize into fine powder to obtain propolis flavonoid extract.

Embodiment 3

[0053] Preparation of dropping pills

[0054] Take 83g of propolis flavonoid extract and 3 times the amount of polyethylene glycol 6000, mix, melt, drip, cool, and dry to make drop pills. Other items should comply with the relevant requirements of the 2000 edition of the Pharmacopoeia of the People's Republic of China.

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PUM

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Abstract

The invention provides a process for preparing bee glue flavone extract, its medicinal preparation and novel medical use, wherein the preparation process comprises, freezing and crushing the bee glue into coarse powder, charging in alcohol proportionally for lixiviating, filtering and combining the filter liquor, reclaiming the solvent by depression, condensing into thick grease, decompressing and drying, disintegrating into fines, dissolving by chloroform-ethanol miscible liquid, and extracting with sodium-hydroxide solution of equal volume, adjusting pH to 4-8 by charging in hydrochloric acid into alkaline extract liquor, obtaining deposition, filtering by suction, rinshing to neutral, decompressing and drying, disintegrating into fines, thus the product according to the invention can be obtained.

Description

technical field [0001] The invention relates to a new method for extracting and purifying propolis flavonoids, pharmaceutical preparations and new uses thereof, including the effects of propolis flavonoids in treating coronary heart disease, angina pectoris, hyperlipidemia, etc., and belongs to the field of traditional Chinese medicine or natural medicine. Background technique [0002] Propolis is a complex compound of resinous substances collected by bees from the axillary buds of collagen plants and bee endocrine. The chemical composition of propolis is very complex. Through chromatographic and mass spectrometric analysis, there are more than 20 flavonoids that have been isolated and confirmed. Conventional propolis products are compressed into tablets after dewaxing propolis and adding other auxiliary materials. Each tablet contains no less than 3 mg of flavonoids based on anhydrous rutin (equivalent to 100 mg of original propolis). Extract. As a natural medicine, propo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30A61K31/352A61K9/20A61K9/16A61K9/48A61K9/10A61K9/08A61P3/06A61P9/10
Inventor 隋殿军杨明焦连庆
Owner CHANGCHUNG COLLEGE OF TRADITIONAL CHINESE MEDIICINE
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