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Composition, extraction process and use of total triterpene sapogenin extracted from bamboo

A technology for total saponins and sapogenins is applied in the field of composition of triterpenoid total sapogenins, which can solve the problems of long process flow, high content of heavy metals and pesticide residues, poor operating environment and the like, and achieves the effect of broad application prospects.

Inactive Publication Date: 2006-08-23
张英 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extraction with chemical solvents not only has a long process flow, large solvent consumption, and poor operating environment, but more importantly, the product quality of the extract is unstable, prone to high levels of heavy metals and pesticide residues, and the extraction yield is low

Method used

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  • Composition, extraction process and use of total triterpene sapogenin extracted from bamboo
  • Composition, extraction process and use of total triterpene sapogenin extracted from bamboo
  • Composition, extraction process and use of total triterpene sapogenin extracted from bamboo

Examples

Experimental program
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Effect test

Embodiment approach

[0070] Put Zhuru powder (generally controlled at 10-20 mesh particle size) into CO 2 In a supercritical extraction kettle, at a temperature of 50-65 °C, a pressure of 25-35 MPa, and with or without entraining agent, cyclic dynamic extraction is carried out for 2-5 hours to obtain the extract of Bamboo Ruba (EZR 2002 ). The entraining agent used can be organic solvents such as methanol, ethanol and acetone, and the dosage is generally CO 2 5-15% of the amount (v / v).

[0071] The following preferred examples describe the present invention in detail, but are not intended to limit the present invention.

example 1

[0072] Example 1 Put 5.5kg of Phyllostachys nigra var.henonis (Phyllostachys nigra var.henonis, also known as Phyllostachys nigra var. 2 The pump is boosted to 30 MPa, and enters the extraction kettle through the preheater; the entrainer pump is turned on, so that 10% volume ratio of acetone passes through the preheater and enters the extraction kettle at the same time, and the dynamic extraction is carried out at 55 ° C for 3 hours. Separation kettle 1 sets separation pressure to 8 MPa and temperature to 45°C, separation kettle 2 sets separation pressure to 5-6 MPa and temperature to 27-30°C; take out the target product from separation kettle 1 and dry at low temperature , after pulverization, the extract of Zhuru (EZR 2002 ) 121 grams, the productive rate is about 2.2%;

example 2

[0073] Example 2 In addition to using bamboo (Phyllostachys pubescens, also known as bamboo) as raw material, the extraction temperature is 60 ° C, the pressure is 25 MPa, and the time is 5 hours, except that the entrainer is changed to 10% ethanol by volume, the rest Same conditions as Example 1, EZR 2002 The yield is about 1.8%.

[0074] The present invention also provides supercritical CO 2 The Zhuru extract (code-named as EZR) obtained by extraction means 2002 ) product characteristics.

[0075] EZR 2002 It is a mixture of pentacyclic triterpenoids mainly composed of suberone, lupenone and their homologues. The appearance is yellow or yellow-green powder, and the melting point is between 74 and 79°C. The infrared spectrogram after potassium bromide compression shows that the mixture has -1There are characteristic absorption peaks (see attached figure 1 ). will EZR 2002 After dissolving in spectroscopically pure dichloromethane, scanning in the wavelength range of 3...

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Abstract

The present invention discloses the composition, extraction process and use of total triterpene sapogenin extracted from bamboo. The triterpene sapogenin is extracted from stem, branch, leaf, root, shoot, etc. of bamboo as one kind of gramineous plant via supercritical CO2 fluid extraction process. The test via vanillin-perchloric acid colorimetry method and GC-MS method shows that the extractive has total triterpene sapogenin content of 10-90 %, friedelin content of 5-35 % and lupenone content of 1-10 %. The extractive as one mixture of five-cycle triterpene compounds (EZR2002) has excellent physiological and pharmacological activity of resisting free radical, resisting oxidation, resisting tumor, lowering blood pressure, etc. and may be used in medicine and health care article for preventing and treating cardiac and cerebral vascular diseases and resisting tumor and may be also used in cosmetics.

Description

technical field [0001] The invention relates to the composition, method and application of triterpene total saponins extracted from bamboo. The present invention uses supercritical CO 2 Fluid extraction technique extracts triterpenoids from bamboo, which is a group of pentacyclic triterpenoids (EZR 2002 ), can be used as medicine and health product for preventing and treating cardiovascular and cerebrovascular diseases and antitumor, and can be applied to the field of daily cosmetics. Background technique [0002] Bamboo belongs to the subfamily Bambusoideae of Gramineae and is one of the most valuable natural plants in the world. There are more than 70 genera and more than 1,200 species in the world, and the bamboo forest area is about 20 million ha. my country is the main bamboo producing country in the world, with a bamboo forest area of ​​about 4 million ha. my country's bamboo forest area accounts for 0.5% of the country's land area, accounti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00A61K31/58A61K8/63A61P9/10A61P35/00A23L1/30A61K31/704A61K36/899A61P9/00A61P25/28B01D11/02
CPCA61K36/899A61K31/704B01D11/0203A61P9/00A61P9/04A61P9/10A61P9/12A61P25/28A61P35/00A61P39/06B01D11/0288
Inventor 张英吴晓琴俞卓裕朱云龙陈林根罗生根
Owner 张英
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