Medicine composition
A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, skin diseases, etc., to achieve obvious excretion effect, eliminate skin roughness and pimples
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[0028] List experimental examples and test examples below to describe the present invention in detail, but the present invention is not limited to these
[0029] Examples etc.
Embodiment 1
[0082] (a) Fabrication of center tablet
[0083] The center tablet (original tablet) composed of Table 3 below was used to make 55 mg tablets each with a pestle of 5.5 mmφ and 4.5 R. The hardness of this tablet was 2.8 kgf, and the disintegration time (test liquid; water) was 6 to 8 minutes.
[0084] Element
1 tablet (mg)
Bisacodyl
5.0
Calcium Sennoside
13.3
Vitamin B 6 (Vitamin B hydrochloride 6 )
5.0
Vitamin B 2 (riboflavin)
2.0
Microcrystalline Cellulose PH-101
5.5
lactose
22.7
Talc
0.5
Magnesium stearate
1.0
total
55.0
[0085] 4.7 kg of the tablet was loaded into a ventilated flat bottom coating machine (Hicoater HCT-48; manufactured by Freund Industry Co., Ltd.), at a supply air temperature of 50° C., an article temperature of 45° C., and a rotation speed of 16 revolutions per minute (rpm) Under conditions, the plasticizer solu...
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