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Human TOLL-like receptor proteins, related reagents and methods

A protein and fusion protein technology, applied in chemical instruments and methods, animal/human proteins, botanical equipment and methods, etc., can solve the problems of cells that cannot maintain the immune system in vitro, hinder the research of immune disorders, etc.

Inactive Publication Date: 2000-08-16
SCHERING AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The general inability to maintain cells of the immune system in vitro has hampered research to better understand and treat various immune disorders

Method used

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  • Human TOLL-like receptor proteins, related reagents and methods
  • Human TOLL-like receptor proteins, related reagents and methods
  • Human TOLL-like receptor proteins, related reagents and methods

Examples

Experimental program
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Effect test

Embodiment I

[0141] Example I. General method

[0142] Certain standard methods are described and cited, for example, in Maniatis et al. (1982) Molecular Cloning, A Laboratory Guide, Cold Spring Harbor Laboratory, Cold Spring Harbor Press, NY; Sambrook et al. (1989) Molecular Cloning: A Laboratory Guide (pp. 2 editions) Vols 1-3, CSH Press, NY; Ausubel et al., Biology, Greene Publishing Associates, Brooklin, NY; or Ausubel et al. (1987 and supplements) Current Protocols in Molecular Biology, Wiley / Greene, NY. Methods for protein purification include methods such as ammonium sulfate precipitation, column chromatography, electrophoresis, centrifugation, crystallization and others. See, eg, Ausubel et al. (1987 and regular supplements); Coligan et al. (eds., 1996) and regular supplements, Current Protocols In Protein Science, Wiley / Greene, NY; Deutscher (1990) Methods in Enzymology Vol. 182 and in this series "Protein Purification Guidelines" in other volumes in ; and ma...

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PUM

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Abstract

Nucleic acids encoding nine human receptors, designated DNAX Toll-like receptors 2-10 (DTLR2-10), homologous to the Drosophila Toll receptor and the human IL-1 receptor, purified DTLR proteins and fragments thereof, mono- / polyclonal antibodies against these receptors, and methods for diagnostic and therapeutic use.

Description

[0001] This application claims priority to US Patent Applications USSN 60 / 044,293, filed May 7, 1997, USSN 60 / 072,212, filed January 22, 1998, and USSN 60 / 076,947, filed March 5, 1998, which Each of is incorporated herein by reference. field of invention [0002] The present invention relates to compositions and methods of affecting mammalian physiology, including morphogenesis or immune system function. In particular, the invention provides nucleic acids, proteins and antibodies that modulate development and / or the immune system. Diagnostic and therapeutic uses of these substances are also disclosed. Background of the invention [0003] Recombinant DNA techniques generally refer to those techniques by which genetic information from a donor source is incorporated into a vector for subsequent processing, such as by introduction into a host, whereby the transferred genetic information is Reproduced and / or expressed in. Typicall...

Claims

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Application Information

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IPC IPC(8): C12N15/09C07K14/705C07K16/28C07K19/00C12N1/15C12N1/19C12N1/21C12N5/10C12N15/12C12P21/02
CPCC07K2319/00C07K14/705C07K14/00C12N15/63
Inventor G·T·哈迪曼F·L·罗克J·F·巴赞R·A·卡斯特莱恩
Owner SCHERING AG
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