Medicinal composition containing triphenyl-boroxin for boron neutron catching treatment

A composition, boron neutron technology, applied in the direction of drug combination, boron compound active ingredients, antineoplastic drugs, etc., can solve problems such as the demand for boron-containing drugs, and achieve the effect of high stability

Inactive Publication Date: 2006-06-28
周凤英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] A main purpose of the present invention is to provide a boron-containing drug that can be selectively accumulated in high concentrations in cancer cells to solve the demand for boron-containing drugs for boron neutron capture therapy

Method used

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  • Medicinal composition containing triphenyl-boroxin for boron neutron catching treatment
  • Medicinal composition containing triphenyl-boroxin for boron neutron catching treatment
  • Medicinal composition containing triphenyl-boroxin for boron neutron catching treatment

Examples

Experimental program
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Effect test

Embodiment

[0031] Preparation of triphenylboroxine (phenylboronic anhydride) iodized poppy oil (triphenylboroxin entrappedlipiodol, TEL):

[0032] Take a round bottom flask, add appropriate amount of iodized poppy oil, linoleic acid, lecithin, add appropriate amount of absolute alcohol and heat at 70°C for 20 minutes, after it is completely clear, add appropriate amount of triphenyl boron ring in the above preparation example Oxane (phenylboronic anhydride) solution, continue heating and stirring for 10 minutes. The anhydrous alcohol was completely removed at 50°C with a vacuum concentration and extraction system, and the finally obtained light yellowish brown clear oil was triphenylboroxine (phenylboronic anhydride) iodized poppy oil. The optimum ratio of each composition is triphenylboroxine (phenylboronic anhydride) solution: iodized poppy oil: lecithin: linolenic acid: dehydrated alcohol=0.03ml: 1ml: 20mg: 0.06ml: about 30ml .

[0033] Alpha trajectory test of triphenylboroxine (ph...

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Abstract

The present invention relates to medicinal composition for boron neutron catching treatment, and is a kind medicinal composition for catching boron neutron to treat liver cancer. The medicinal composition includes triphenyl boroxin as the boron source for boron neutron catching treatment and pharmaceutically acceptable carrier, such as iodized opium poppy seed oil.

Description

technical field [0001] The present invention relates to a medical composition for boron neutron capture therapy (boron neutron capture therapy, hereinafter referred to as BNCT), in particular to a medicinal composition containing triphenylboroxine (phenylboronic anhydride) as a boron source. The pharmaceutical composition of BNCT. Background technique [0002] The inventor of this case discloses a boron-containing iodized poppy oil suitable for boron neutron capture therapy of liver cancer in U.S. Patent No. 6,117,852, which is composed of iodized poppy oil, submicron boron powder, lecithin and C12-C22 fatty acid ( such as linoleic acid). The iodized poppy oil has high accumulative property in liver cancer cells, the lecithin has boron powder carrying capacity, and the C12-C22 fatty acid has the property of helping the lecithin dissolve in the iodized poppy oil. The submicron boron powder must have an appropriate particle size distribution range to be evenly distributed in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/69A61P43/00A61P35/00
Inventor 周凤英
Owner 周凤英
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