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Method for microwave extracting nimbin from nim kernal

An extraction method and azadirachtin technology, which are applied in chemical instruments and methods, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as harm to human health, large solvent consumption, and long process flow, and achieve product quality. The effect of improving and improving production efficiency and high economic value

Inactive Publication Date: 2005-05-04
云南中科生物产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional solvent method for extracting azadirachtin not only has long process flow, large solvent consumption, low yield and high cost, but also pollutes the environment and endangers human health.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Put 15g of crushed neem seeds into a 250ml round-bottomed flask, add 150ml of petroleum ether, and irradiate it with microwaves with a power of 300w and a frequency of 2450MHz in 3 times, each time for 1min. After filtering, put the filter residue into a 250ml round-bottomed flask, add 150ml of methanol, and then irradiate it with a microwave with a power of 300w and a frequency of 2450MHz, and divide it into 3 times, each time for 2min, filter, and combine the filtrates extracted with methanol Afterwards, it was distilled under reduced pressure and dried to obtain 0.63 g of a light yellow powdery solid product, and the content of azadirachtin was 9.5% as measured by high performance liquid chromatography.

Embodiment 2

[0017] Put 15g of crushed neem seeds into a 250ml round-bottomed flask, add 150ml of petroleum ether, and irradiate it with microwaves with a power of 300w and a frequency of 2450MHz in 3 times, each time for 1min. After filtering, put the filter residue into a 250ml round-bottomed flask, add 150ml of acetone, and then irradiate it with a microwave with a power of 300w and a frequency of 2450MHz, and divide it into 3 times, each time for 2min, filter, and combine the filtrates extracted with acetone Afterwards, it was distilled under reduced pressure and dried to obtain 0.68 g of a light yellow powdery solid product, and the content of azadirachtin was 8.8% as measured by high performance liquid chromatography.

Embodiment 3

[0019] Put 15g of crushed neem seeds into a 250ml round-bottomed flask, add 150ml of petroleum ether, and irradiate it with microwaves with a power of 300w and a frequency of 2450MHz in 3 times, each time for 1min. After filtering, put the filter residue into a 250ml round-bottomed flask, add 150ml of chloroform, and then irradiate it with a microwave with a power of 300w and a frequency of 2450MHz in 3 times, each time for 2min, and filter with chloroform After the extracted filtrates were combined, they were distilled under reduced pressure and dried to obtain 0.67 g of a light yellow powdery solid product. The content of azadirachtin was 9.0% as measured by high performance liquid chromatography.

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PUM

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Abstract

The invention discloses a method of treating neem seeds in petroleum ether, methanol, ethanol, acetone, ethyl acetate, dichloromethane, chloroform, water or a mixture thereof using microwaves with a frequency of 2450 MHz and a power of 100 to 850 W. Process in a solvent to extract azadirachtin from neem seeds. Compared with the conventional chemical method, the method has the advantages of simplicity, high efficiency, rapidity, low cost, less waste liquid discharge, and high purity of the obtained product.

Description

technical field [0001] The invention relates to a method for extracting azadirachtin from neem seeds by adopting microwave technology. Background technique [0002] Neem, as a "tree that can solve global problems", has attracted more and more attention, and azadirachtin, which is extracted from the fruit-bearing seeds of the neem tree, is the most effective active ingredient with anti-inflammatory, Excellent effects such as sterilization, antipruritic, and insect repellent are more and more used in the fields of pesticides, medicines, and daily chemicals. However, the traditional solvent method for extracting azadirachtin not only has long process flow, large solvent consumption, low yield and high cost, but also pollutes the environment and endangers human health. Contents of the invention [0003] The object of the present invention is to provide a method for extracting azadirachtin from neem kernels by using microwave technology. The microwave it uses is a high-freque...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07G99/00C07H1/08C07H15/26
Inventor 张征梁庆宗乾收武永昆曾文全文胜苏鹏娟马红兵冯沙克林军
Owner 云南中科生物产业有限公司
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