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Use of timosaponin for preparing medicine for preventing and treating brain apoplexy

A technology of timothy saponins and total saponins, applied in the field of medicine, can solve the problems such as unseen total timothy saponins and the like

Inactive Publication Date: 2005-05-04
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there is no report on the use of total saponins of timosapon in the prevention and treatment of stroke

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0011] The preparation method of the total saponins of Anemarrhena in the present invention is as follows: heat extract the crushed Anemarrhena medicinal material with 20-95% ethanol according to the routine, and the amount of the solvent for the first time is about 4 to 8 times of the weight of the crude drug; or use 20 ~95% ethanol percolation extraction, solvent consumption is about 4~12 times of crude drug amount; The extract is concentrated, and the concentrate is centrifuged or filtered; The centrifugal supernatant or filtrate of the concentrate is absorbed by macroporous resin (macroporous resin is Polystyrene-type porous adsorption resin with styrene as bridging material, such as D101, D201, ZTC-1, AB-8, 1300-1 type macroporous resin, etc.), rinse with water and ethanol below 20% to remove Impurities; then eluted with water-containing lower alcohols, such as methanol, ethanol or propanol C 1 ~C 5 Alcohols, the concentration is 30-95%, the dosage is 5-15 times of the c...

Embodiment 1

[0056] Example 1 Preparation of total timosaponins

[0057] Put 100 kg of pulverized anemarrhena medicinal materials into the extraction tank, heat-extract three times with 400 liters of 70% ethanol at 90-100 ° C, each extraction time is 90 minutes, combine the three extracts, concentrate to 80 liters, and filter , the filtrate was adjusted to 100 liters with distilled water. Then slowly pass through the adsorption column that 350 liters of ZTC-1 type macroporous resin (produced by Tianjin Zhengtiancheng Clarification Technology Co., Ltd.) is housed, remove impurities by eluting with 500 liters of distilled water and 1000 liters of 20% ethanol, and then use 1000 liters of 45% ethanol to remove impurities. Eluted with ethanol, collected the eluate, concentrated to dryness, dried and pulverized to obtain a yellow powder, which was the total saponins of Anemarrhena of the present invention, weighing 2.7 kg in total, and the yield was 2.7% based on crude drug amount.

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PUM

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Abstract

An use of common timosaponin in preparing medicine or food for preventing and treating cerebral apoplexy is disclosed.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to the application of total timosaponin in preparing medicine or food for preventing and treating cerebral apoplexy (stroke). Background technique: [0002] Zhimu is the rhizome of Anemarrhena asphodeloides Bunge, a plant of the Liliaceae family. It has the effects of nourishing yin and reducing fire, moistening dryness and smoothing the intestines. It is mostly used clinically for diabetes syndrome. At present, Anemarrhena anemarrhena is mainly used as single-flavored Anemarrhena decoction pieces or decocted with other traditional Chinese medicines. [0003] The chemical components of Anemarrhena are mainly saponins and flavonoids, among which there are more than 20 kinds of saponins that have been reported, such as timosaponin AI, timosaponin AIII, timosaponin B, timosaponin BI, timosaponin BII, Timosaponin BIII, Timosaponin BIV, Timosaponin BV, Timosaponin BVI, Xilingsaponin B, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/11A61K31/58A61P9/10A61P25/00
Inventor 陈万生邱彦殷学平陶朝阳李铁军娄子洋
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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