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Methods of reducing astringency of stannous in dentifrice compositions

A technology of composition and dentifrice, which is applied in the direction of drug combination, dentistry, and pharmaceutical formulations, and can solve the problems of reducing the effectiveness of stannous

Inactive Publication Date: 2004-06-23
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poloxamers or polyphosphates reduce astringency but do not reduce stannous potency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] First dentifrice composition Second dentifrice composition

[0071] Component Weight % Component Weight %

[0072] Carboxymethylcellulose 0.700 Pigment 0.200

[0073] Water 11.500 Water 33.800

[0074] Flavor 0.900 Flavor 0.900

[0075] Glycerin 7.000 Glycerin 41.500

[0076] Hydroxyethylcellulose 0.400 Poloxamer 407 21.00

[0077] Sorbitol 39.596 Xylitol 2.200

[0078] Sodium Lauryl Sulfate(a) 6.000 Sodium Saccharin 0.400

[0079] Silica 28.000

[0080] Sodium hydroxide (b) 0.800

[0081] Sodium saccharin 0.400

[0082] Sodium gluconate 2.100

[0083] Stannous chloride 2.100

[0084] Stannous fluoride 0.454

[0085] (a) 27.9% solution

[0086] (b) 50% solution

[0087] Prepare a first dentifrice composition by adding water, sorbitol, and saccharin to a mixing vessel and heating to at least 50°C. Add the sodium gluconate and mix until completely dissolved. Add stannous fluoride and mix until complete solution. Add stannous chloride and mix until completely...

Embodiment II

[0090] First dentifrice composition Second dentifrice composition

[0091] Component Weight % Component Weight %

[0092] Carboxymethylcellulose 0.500 Sodium hydroxide (b) 1.000

[0093] Water 2.768 Pigment 0.300

[0094] Flavoring 1.000 Water 21.840

[0095] Glycerin 36.432 Flavoring agent 1.000

[0096] Polyethylene glycol 1.500 Glycerin 28.992

[0097] Propylene Glycol 8.000 Sodium Gluconate 4.160

[0098] Sodium Lauryl Sulfate(a) 4.000 Stannous Chloride 3.000

[0099] Silicon dioxide 28.000 Silicon dioxide 23.000

[0100] Benzoic Acid 0.600 Sodium Saccharin 0.300

[0101] Sodium Benzoate 0.600 Poloxamer 15.500

[0102] Sodium saccharin 0.300 Stannous fluoride 0.908

[0103] Titanium dioxide 1.000

[0104] Xanthan gum 0.300

[0105] Glass H polyphosphate 15.000

[0106] (a) 27.9% solution

[0107] (b) 50% solution

Embodiment III

[0109] First dentifrice composition Second dentifrice composition

[0110] Component Weight % Component Weight %

[0111] Carboxymethylcellulose 0.500 Sodium hydroxide (b) 0.746

[0112] Water 2.768 Pigment 0.300

[0113] Flavoring 1.000 Water 21.840

[0114] Glycerin 32.200 Flavoring agent 1.000

[0115] Benzoic acid 0.600 Glycerin 31.016

[0116] Propylene Glycol 8.000 Sodium Gluconate 3.290

[0117] Sodium lauryl sulfate (a) 8.000 Stannous chloride 2.100

[0118] Silica 19.232 Silica 23.000

[0119] Polyol 40 2.500 Sodium Saccharin 0.300

[0120] Polyoxyethylene 0.500 Stannous Fluoride 0.908

[0121] Sodium saccharin 0.300 Poloxamer 407 15.500

[0122] Titanium dioxide 1.000

[0123] Xanthan gum 0.300

[0124] Glass H polyphosphate 21.000

[0125] Polyethylene glycol 1.500

[0126] Sodium Benzoate 0.600

[0127] (a) 27.9% solution

[0128] (b) 50% solution

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Abstract

Disclosed are methods for reducing the astringency of dentifrice composition containing stannous comprising administering to the subject a dentifrice composition comprising stannous. The dentifrice composition comprises stannous ions, poloxamer, and aqueous carriers. The efficacy of this dentifrice composition containing stannous will not be reduced by the poloxamer. The dentifrice composition may also contain a polyphosphate as long as the water content is limited and the stannous ion is not provided from stannous fluoride. The polyphosphate will also not reduce the efficacy of the stannous. Alternatively, the dentifrice composition may be a dual phase composition. The first dentifrice composition will contain a polyphosphate having an average chain length of about 4 or more and have a limited water content while the second dentifrice composition will contain stannous ions. In the dual phase compisition, the poloxamer will be present in the first or second dentifrice compositions or both compositions. Neither the polyphosphate or the poloxamer will reduce the efficacy of the stannous.

Description

[0001] Related Application Cross Documentation [0002] This application is a continuation-in-part of Application No. 08 / 754,577, filed November 21,1996. Background of the invention [0003] The present invention relates to a method for reducing the astringency of stannous-containing dentifrice compositions. The present inventors have found that the astringency, bitterness and sourness associated with stannous can be reduced using poloxamers. Certain polyphosphates, especially linear polyphosphates with an average chain length of about 4 or more, have also been found to help reduce the astringent taste of stannous. Poloxamers or polyphosphates reduce astringency without reducing the potency of stannous. [0004] The term "stannous" is defined herein as stannous in dentifrices. It can refer to stannous ions provided by stannous salts. Stannous salts containing stannous ions are well known. Stannous was found to provide ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/00A61K8/19A61K8/21A61K8/24A61K8/25A61K8/29A61K8/34A61K8/36A61K8/38A61K8/40A61K8/72A61K8/73A61K8/86A61K8/90A61P1/02A61Q11/00
CPCA61K8/19A61K2800/88A61Q11/00A61K8/90A61K8/21A61K2800/52A61K8/24A61P1/02
Inventor W·M·格兰多尔夫
Owner PROCTER & GAMBLE CO
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