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Synchronous separation method for 160Gd, 161Tb and 161Dy

A synchronous separation, separation and purification technology, applied in the direction of improving process efficiency, can solve the problems of nuclide residues, low sample loading, and difficulty in large-scale Curie-level production.

Pending Publication Date: 2022-08-02
INST OF NUCLEAR PHYSICS & CHEM CHINA ACADEMY OF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] current common 161 Tb production and preparation methods include ion exchange chromatography and lanthanide column separation method, although ion exchange chromatography can realize 160 Gd, 161 Tb, 161 Synchronous separation of the three nuclides of Dy, but the amount of sample loaded is too low, making it difficult to carry out larg

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  • Synchronous separation method for 160Gd, 161Tb and 161Dy
  • Synchronous separation method for 160Gd, 161Tb and 161Dy
  • Synchronous separation method for 160Gd, 161Tb and 161Dy

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Embodiment 1

[0050] figure 1 is the use of single-stage lanthanide resin column synchronous separation 160 Gd, 161 Tb, 161 Schematic diagram of the process flow of Dy.

[0051] In this embodiment, the separation target material is 20 mg after being irradiated by the reactor 160 Gd 2 O 3 Target material (contains about 17.4mg 160 Gd, 0.0008mg 161 Tb, 0.0008mg 161 Dy), the size of the lanthanide resin separation column is that the column volume LV is 5mL, the inner diameter is 8mm, and the length is 10cm. The lanthanide resin type is commercial LN type; the size of the DGA column is that the column volume DV is 0.5mL, the inner diameter is 5mm, and the length is 2.5cm. DGA The resin model is commercial DGA-B type; the acid solutions a, b, and c used are respectively 2M nitric acid, 4M nitric acid, and 9M nitric acid; the used acid solution e is 0.9M nitric acid; the used acid solution f is 14M nitric acid;

[0052] Synchronous separation in this embodiment 160 Gd, 161 Tb, 161 The...

Embodiment 2

[0061] figure 2 synchronous separation using two-stage lanthanide columns 160 Gd, 161 Tb, 161 Schematic diagram of the process flow of Dy.

[0062] In this embodiment, the separation target material is 100 mg after being irradiated by the reactor 160 Gd 2 O 3 Target material (contains about 87.0mg 160 Gd, 0.004mg 161Tb, 0.004mg 161 Dy), the size of the first-stage lanthanide resin separation column is that the column volume LV is 26 mL, the inner diameter is 15 mm, and the length is 15 cm; the size of the second-stage lanthanide resin separation column is that the column volume LV is 5 mL, the inner diameter is 8 mm, and the length is 10 cm. The lanthanide resin The model is the commercial LN2 type. The size of the first-stage DGA column is that the column volume DV is 2mL, the inner diameter is 8mm, and the length is 4cm; the second-stage DGA column size is that the column volume DV is 0.5mL, the inner diameter is 5mm, and the length is 2.5cm. The DGA resin model is...

Embodiment 3

[0081] image 3 synchronous separation using a three-stage lanthanide column 160 Gd, 161 Tb, 161 Schematic diagram of the process flow of Dy. (The lanthanide resin separation column and the DGA solution replacement column used in the third stage are new chromatographic columns)

[0082] In this embodiment, the separation target material is 1000 mg after being irradiated by the reactor 160 Gd 2 O 3 Target material (contains about 869.6mg 160 Gd, 0.04mg 161 Tb, 0.04mg 161 Dy), the size of the first-stage lanthanide resin separation column is that the column volume LV is 247 mL, the inner diameter is 30 mm, and the length is 35 cm; the size of the second-stage lanthanide resin separation column is that the column volume LV is 26 mL, the inner diameter is 15 mm, and the length is 15 cm; the third stage The dimension of the lanthanide resin separation column is that the column volume LV is 5 mL, the inner diameter is 8 mm, and the length is 10 cm, and the model of the lant...

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Abstract

The invention provides a < 160 > Gd, < 161 > Tb and < 161 > Dy synchronous separation method. The method comprises the following steps: preparing a lanthanide column loading solution; adsorbing with a lanthanide column; gradient elution of a lanthanide column; preparing a DGA column sample loading solution; carrying out DGA column adsorption; carrying out DGA column solution replacement; and identifying. According to the 160Gd, 161Tb and 161Dy synchronous separation method provided by the invention, a lanthanide column and DGA column combined process is adopted, synchronous separation of three nuclides of 160Gd, 161Tb and 161Dy in a 160Gd2O3 irradiation target material is realized for the first time, then localized preparation of carrier-free 161Tb nuclides is realized, the blank in the field in China is filled up, and through a multi-stage lanthanide column separation-DGA column solution replacement modular series connection mode, the separation efficiency is greatly improved. According to the method, the series connection number is flexibly adjusted, a 161Tb product meeting the purity requirement of a user is obtained, and Curie-level, ten-Curie-level, hundred-Curie-level and even higher-scale 161Tb preparation can be achieved.

Description

technical field [0001] The invention belongs to the technical field of preparation of medicinal radioisotopes, in particular to a 160 Gd, 161 Tb, 161 Dy sync separation method. Background technique [0002] In recent years, due to the suitable half-life (6.9d) and the release of low energy β - Particles (βav=154keV) and Auger electrons (its capacity≤40keV), accompanying emission of γ-radiation, and their coordination properties and in vivo behavior are related to 177 Lu similarity and other advantages, 161 Tb nuclides have received more and more attention, especially in medical radiopharmaceuticals. [0003] no carrier 161 Tb can react by stacking 160 Gd(n, γ) 161 Gd→ 161 Tb is obtained, and the starting nuclide of this reaction is 160 Gd, the product is 161 Tb, simultaneous product 161 Tb also gradually decays into 161 Dy, so the resulting reaction product is present at the same time 160 Gd, 161 Tb and 161 Dy, due to 161 Dy and 161 The coordination propert...

Claims

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Application Information

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IPC IPC(8): C22B3/24C22B59/00
CPCC22B3/24C22B59/00Y02P10/20
Inventor 赵鹏杨宇川卓连刚党宇峰王静廖伟杨夏王关全熊晓玲魏洪源涂俊
Owner INST OF NUCLEAR PHYSICS & CHEM CHINA ACADEMY OF
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