Melanoma biomarker of urine sample and application of melanoma biomarker

A technology for biomarkers and melanoma, applied in biochemical equipment and methods, microbiological determination/testing, DNA/RNA fragments, etc., can solve problems such as lack of consensus

Pending Publication Date: 2022-07-29
SHENZHEN HAPLOX BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Dysregulation of miRNA expression in cells can lead to the occurrence of various diseases including melanoma. The latest research shows that some miRNAs are abnormally expressed in the blood of melanoma patients, but which miRNA is related to the occurrence and development of melanoma has not yet been determined. consensus

Method used

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  • Melanoma biomarker of urine sample and application of melanoma biomarker

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Embodiment

[0033] In this example, based on the existing literature data, multiple groups of miRNAs theoretically related to melanoma and whose expression is up-regulated or down-regulated are screened as a target miRNA library. A total of 171 miRNA sequences were screened in this case, and the names are shown in Table 1.

[0034] Table 1 Target miRNA library

[0035] let-7a mir-182-5p mir-335 mir-138-5p mir-23a-5p mir-637 let-7a-1 mir-182 mir-337 mir-141 mir-27a mir-661 let-7a-2 mir-182-3p mir-33a mir-142-5p mir-27b mir-663a let-7a-3 mir-186 mir-340 mir-143 mir-29a mir-663b let-7b mir-18a mir-345-5p mir-144 mir-29b mir-675 let-7c mir-191 mir-34a mir-145 mir-29b-1 mir-7 let-7d mir-192 mir-34b mir-146a mir-29b-2 mir-7-5p let-7e mir-193a-3p mir-34c mir-148a mir-29c mir-708-5p let-7f-1 mir-194 mir-367 mir-148b mir-300 mir-744 let-7f-2 mir-195 mi...

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Abstract

The invention discloses a melanoma biomarker of a urine sample and application of the melanoma biomarker. The melanoma biomarker of the urine sample disclosed by the invention is miRNA with a sequence as shown in Seq ID No. 1. The melanoma biomarker of the urine sample is expressed at a high level in the urine of a patient with melanoma, and the expression level in the urine of a normal healthy person is remarkably low; therefore, the melanoma can be judged by detecting the expression level of the melanoma biomarker in a urine sample. The biomarker provides a new scheme and approach for melanoma detection, and is especially suitable for early screening and large-scale screening of melanoma.

Description

technical field [0001] The present application relates to the technical field of melanoma biomarkers, in particular to a melanoma biomarker of urine samples and applications thereof. Background technique [0002] Melanoma originates from melanocytes in the skin and is the most common type of skin cancer, with a high degree of malignancy and a poor prognosis. Often, melanoma has multiple metastases at the time of discovery, resulting in a poor prognosis. [0003] MicroRNA (miRNA) is a class of evolutionarily conserved single-stranded non-coding RNA molecules with a length of about 20 nt. It binds target messenger RNA (mRNA) through complementary base pairing, and guides the degradation of target mRNA or inhibits target mRNA. translation, thereby preventing the production of the target protein. [0004] The dysregulated expression of miRNA in cells can lead to the occurrence of various diseases including melanoma. The latest research shows that some miRNAs are abnormally exp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/113
CPCC12Q1/6886C12N15/113C12Q2600/158C12Q2600/178C12N2310/141
Inventor 许明炎张晓妮林郁松李慧周书雄
Owner SHENZHEN HAPLOX BIOTECH
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