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Preparation method of multilayer nano-liposome

A nano-liposome and distearate technology, which is applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as difficulty in finding lamellar endoplasmic reticulum, decreased effect, and thermodynamic instability , to achieve excellent skin percutaneous absorption, improve the effect, and ensure long-term stability

Pending Publication Date: 2022-07-29
BIOBEAUTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dosage forms are thermodynamically unstable as they must be used at high temperatures, and there are problems in that their effectiveness decreases substantially over time and may have unintended side effects on the skin
[0004] On the other hand, the technique of making liposomes using the molecular clustering method has been less researched, and it is difficult to find a technique for making molecular clusters and making lamellar endoplasmic reticulum by injecting carbon dioxide gas without any organic solvent

Method used

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  • Preparation method of multilayer nano-liposome
  • Preparation method of multilayer nano-liposome
  • Preparation method of multilayer nano-liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～15

[0046] Examples 1-15: Preparation of multilamellar liposomes produced in the molecular cluster state

[0047] In this example, multilamellar liposomes formed in a state of molecular clustering were prepared.

[0048] 1) Preparation of Mixed Surfactant Compositions Comprising the Mixtures of the Invention

[0049] In Examples 1 to 3, hydrogenated phosphatidylcholine, hydrogenated phosphatidylinositol, hydrogenated sucrose distearate, and potassium phosphate were mixed and used instead of general phospholipids based on 100% by weight of the total weight. figure 1 a is the molecular structure of the ingredients used. From these structures, two alkyl chains are bonded to the hydrophilic head group, and only ionically bonded to potassium phosphate of potassium phosphate. From these structures, hydrogenated phosphatidylcholine and hydrogenated phosphatidylinositol components were selected as phospholipid components to prepare liposome endoplasmic reticulum, thereby producing stabl...

Embodiment 16～24

[0074] The results show that in Examples 12 to 15 using 1 to 5% by weight of the mixed surfactant, the multilamellar liposome production effect was good, and unlike Comparative Example 7 using general phospholipids, it was stable. Examples 16-24: Preparation of compositions containing multilamellar liposomes encapsulating ingredients to be encapsulated using Example 2

[0075] In this example, a composition containing multilamellar liposomes encapsulating the active ingredient was prepared using the mixed surfactant of Example 2 prepared above. The detailed compositions and results are shown in Tables 6 and 7 below.

[0076] Table 6.

[0077]

[0078]

[0079] Table 7.

[0080]

[0081] As a result, as shown in Table 6, it was found that multilamellar liposomes encapsulating various components to be encapsulated in Examples 16 to 23 were stably produced. In addition, in Table 7, it was found that 320 nm liposomes were stably produced in Example 24 compared to Compa...

Embodiment 25～27

[0082] Examples 25 to 27: Preparation of cosmetic compositions (skin care essences) containing multilamellar liposomes of the present invention

[0083] In this example, cosmetic compositions containing the prepared multilamellar liposome compositions (Examples 16 to 18) were prepared. In one example, a skin care serum was prepared with the detailed ingredients shown in Table 8 below.

[0084] Table 8.

[0085]

[0086]

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Abstract

The invention relates to a method for preparing a multilayer nanoliposome, which comprises the following steps: (a) injecting carbon dioxide into a mixture containing hydrogenated phosphatidylcholine, hydrogenated phosphatidylinositol, hydrogenated sucrose distearate and potassium phosphate, dissolving the mixture in the carbon dioxide in a molecular clustering state, (b) adding a to-be-encapsulated component and stirring; (c) dispersing in a hydrophilic solvent to prepare a multilayer liposome; and (d) preparing the multi-layer nano-liposome through a high-pressure microfluidizer to prepare the more stable multi-layer liposome. According to the method disclosed by the invention, the more stable multilayer lipidosome can be prepared. Furthermore, it is possible to prepare a cosmetic composition containing liposomes that more stably encapsulate various components to be encapsulated, ensure long-term stability thereof, and exhibit excellent skin transdermal absorption ability, skin moisturizing effect, antioxidant ability, and skin elasticity improving effect.

Description

technical field [0001] The present invention relates to a manufacturing method for further improving stability by encapsulating active ingredients in a multi-layered liposome structure in a state of molecular clustering, and a cosmetic composition containing the method. More specifically, it provides a method of injecting carbon dioxide into into a mixture containing hydrogenated phosphatidylcholine, hydrogenated phosphatidylinositol, hydrogenated sucrose distearate and potassium phosphate, and the multilamellar liposomes produced after dissolving in the molecular cluster state, and the method containing Cosmetic composition. Background technique [0002] For traditional liposomes, first, phospholipids are used to heat and dissolve them in an organic solvent, then, active ingredients are added for encapsulation, and the process of heating and removing the organic solvent generates a higher temperature, at this time, the active ingredients are destroyed. Or decompose, unable...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/35A61K8/49A61K8/55A61K8/60A61K8/63A61K8/67A61K8/96A61K8/9789A61Q19/00A61Q19/08
CPCA61K8/14A61K8/553A61K8/60A61K8/676A61K8/678A61K8/671A61K8/675A61K8/4986A61K8/498A61K8/4946A61K8/63A61K8/35A61K8/355A61K8/9789A61K8/965A61K8/606A61Q19/08A61Q19/00A61K2800/805
Inventor 金仁荣
Owner BIOBEAUTECH CO LTD
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