Preparation method of multilayer nano-liposome
A nano-liposome and distearate technology, which is applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as difficulty in finding lamellar endoplasmic reticulum, decreased effect, and thermodynamic instability , to achieve excellent skin percutaneous absorption, improve the effect, and ensure long-term stability
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Embodiment 1~15
[0046] Examples 1-15: Preparation of multilamellar liposomes produced in the molecular cluster state
[0047] In this example, multilamellar liposomes formed in a state of molecular clustering were prepared.
[0048] 1) Preparation of Mixed Surfactant Compositions Comprising the Mixtures of the Invention
[0049] In Examples 1 to 3, hydrogenated phosphatidylcholine, hydrogenated phosphatidylinositol, hydrogenated sucrose distearate, and potassium phosphate were mixed and used instead of general phospholipids based on 100% by weight of the total weight. figure 1 a is the molecular structure of the ingredients used. From these structures, two alkyl chains are bonded to the hydrophilic head group, and only ionically bonded to potassium phosphate of potassium phosphate. From these structures, hydrogenated phosphatidylcholine and hydrogenated phosphatidylinositol components were selected as phospholipid components to prepare liposome endoplasmic reticulum, thereby producing stabl...
Embodiment 16~24
[0074] The results show that in Examples 12 to 15 using 1 to 5% by weight of the mixed surfactant, the multilamellar liposome production effect was good, and unlike Comparative Example 7 using general phospholipids, it was stable. Examples 16-24: Preparation of compositions containing multilamellar liposomes encapsulating ingredients to be encapsulated using Example 2
[0075] In this example, a composition containing multilamellar liposomes encapsulating the active ingredient was prepared using the mixed surfactant of Example 2 prepared above. The detailed compositions and results are shown in Tables 6 and 7 below.
[0076] Table 6.
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[0079] Table 7.
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[0081] As a result, as shown in Table 6, it was found that multilamellar liposomes encapsulating various components to be encapsulated in Examples 16 to 23 were stably produced. In addition, in Table 7, it was found that 320 nm liposomes were stably produced in Example 24 compared to Compa...
Embodiment 25~27
[0082] Examples 25 to 27: Preparation of cosmetic compositions (skin care essences) containing multilamellar liposomes of the present invention
[0083] In this example, cosmetic compositions containing the prepared multilamellar liposome compositions (Examples 16 to 18) were prepared. In one example, a skin care serum was prepared with the detailed ingredients shown in Table 8 below.
[0084] Table 8.
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