Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation method of crystalized drug coating on surface of coronary balloon

A technology of drug coating and balloon, applied in the direction of coating, catheter, etc., which can solve the problems of low drug transfer rate on the surface of the balloon, reducing drug load, falling, etc.

Pending Publication Date: 2022-07-26
HANGZHOU BARTY MEDICAL TECH CO LTD
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional dip-coating process uses direct drying to volatilize the solvent, which cannot make the drug crystallize on the surface of the balloon. During the process of solvent drying and volatilization, most of the drug on the surface of the balloon will be powdered and will fall from the surface of the balloon. , so as to reduce the drug loading on its surface, so that the drug transfer rate on the balloon surface is low

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of crystalized drug coating on surface of coronary balloon
  • Preparation method of crystalized drug coating on surface of coronary balloon
  • Preparation method of crystalized drug coating on surface of coronary balloon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of a crystalline drug coating on the surface of a coronary balloon, comprising the following steps;

[0027] (1) Preparation of drug solvent, mix 50ml of acetone and 50ml of isobutanol to obtain a drug solvent;

[0028] (2) preparing a drug solution, dissolving the loaded drug in the drug solvent, the loaded drug is paclitaxel, the concentration of the paclitaxel is 150 mg / ml, and the drug dip coating solution is obtained after ultrasound;

[0029] (3) Inflate the balloon, connect the coronary balloon to the three-way valve, the shape of the coronary balloon is cylindrical with a diameter of 3.0mm and a length of 20mm, inject 2ml of gas with a syringe, and blow up the coronary balloon sac, the coronary artery balloon is sterilized for subsequent use;

[0030] (4) The sterilized coronary balloon is immersed in the drug dip coating solution, and the dip coating is performed by immersing the coronary balloon in the drug dip coating solution for 5s, an...

Embodiment 2

[0033] A preparation method of a crystalline drug coating on the surface of a coronary balloon, comprising the following steps;

[0034] (1) To prepare a drug solvent, mix 50ml of acetone and 55ml of isobutanol to obtain a drug solvent;

[0035] (2) preparing a drug solution, dissolving the loaded drug in the drug solvent, the loaded drug is paclitaxel, the concentration of the paclitaxel solution is 120 mg / ml, and the drug dip coating solution is obtained after ultrasound;

[0036] (3) Inflate the balloon, connect the coronary balloon to the three-way valve, the shape of the coronary balloon is a cylindrical shape of 3.0mm in diameter and 20mm in length, inject 2.5ml of gas with a syringe, and blow up the coronary artery Balloon, the coronary artery balloon is sterilized for later use;

[0037] (4) The sterilized coronary balloon is immersed in the drug dip coating solution, and the dip coating is performed by immersing the coronary balloon in the drug dip coating solution f...

Embodiment 3

[0040] A preparation method of a crystalline drug coating on the surface of a coronary balloon, comprising the following steps;

[0041] (1) Preparation of drug solvent, mix 50ml of acetone and 60ml of isobutanol to obtain a drug solvent;

[0042] (2) preparing a drug solution, dissolving the loaded drug in the drug solvent, the loaded drug is paclitaxel, the concentration of the paclitaxel solution is 130 mg / ml, and the drug dip coating solution is obtained after ultrasound;

[0043] (3) Inflate the balloon, connect the coronary balloon to the three-way valve, the shape of the coronary balloon is cylindrical with a diameter of 3.0mm and a length of 20mm, inject 3ml of gas with a syringe, and blow up the coronary balloon sac, the coronary artery balloon is sterilized for subsequent use;

[0044] (4) The sterilized coronary balloon is immersed in the drug dip coating solution for dip coating. The dip coating is performed by immersing the coronary balloon in the drug dip coating ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
lengthaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of a crystalized drug coating on the surface of a coronary balloon, and belongs to the technical field of drug loading. The preparation method comprises the following steps: (1) mixing acetone and isobutanol to obtain a drug solvent; (2) dissolving a loaded drug in a drug solvent, adding ethanol, and carrying out ultrasonic treatment to obtain a drug dip-coating solution; (3) blowing the coronary balloon for later use; (4) immersing the coronary balloon in the medicine dip-coating solution to obtain the coronary balloon coated with the medicine; and (6) loading the coronary balloon into a negative pressure device, crystallizing, and taking out to obtain the coronary balloon loaded with the crystal drug coating. The medicine is combined on the surface of the coronary balloon in a dip-coating mode, the medicine on the surface of the coronary balloon is subjected to crystallization growth through vacuum operation, the obtained medicine layer on the surface of the coronary balloon is uniform and free of stripping, the balloon is not exposed, crystals are fine, and the medicine loading capacity is stable.

Description

technical field [0001] The invention belongs to the technical field of drug loading, and particularly relates to a preparation method of a crystalline drug coating on the surface of a coronary balloon. Background technique [0002] With the gradual improvement of people's living standards and changes in lifestyle, the number of cardiovascular diseases in the world is also increasing year by year. Cardiovascular disease has also become an important disease threatening human health. Drug balloon has a good therapeutic effect in the treatment of intravascular restenosis. [0003] In the early 21st century, drug eluting stent (DES) opened a new chapter in interventional therapy. The difference between drug-eluting metal stents and bare metal stents is that the surface is covered with drugs such as paclitaxel or rapamycin. The eluted drugs can inhibit cell proliferation, help prevent coronary artery restenosis or reocclusion, and can significantly reduce Incidence of postopera...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/16A61L29/08
CPCA61L29/16A61L29/08A61L2300/416A61L2300/216A61L2300/606A61L2420/02
Inventor 杜瑞林王志
Owner HANGZHOU BARTY MEDICAL TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com