Application of Pak3 inhibitor in treatment of remifentanil-induced incision hyperalgesia

A kind of hyperalgesia, pak3 technology, applied in the field of biomedicine, can solve the problem of unclear mechanism, reducing the analgesic effect of drugs, increasing hospitalization time, etc.

Active Publication Date: 2022-07-22
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

RIH not only reduces the analgesic effect of drugs, but also promotes pain perception, produces abnormal pain, and even causes postoperative chronic pain. The most important thing is to increase the physical and mental trauma of patients, aggravate the pain of patients, and seriously affect the quality of life of patients
At present, there is no effective clinical treatment, mainly because its mechanism is still unclear. Therefore, it is urgent to clarify the pathogenesis of remifentanil-induced hyperalgesia and find effective treatment strategies

Method used

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  • Application of Pak3 inhibitor in treatment of remifentanil-induced incision hyperalgesia
  • Application of Pak3 inhibitor in treatment of remifentanil-induced incision hyperalgesia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] Example Study on the correlation between Pak3 and remifentanil-induced incision pain

[0034] 1. Experimental steps

[0035] (1) Experimental grouping: 40 male C57BL6 mice, 1 month old, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army. The random number table method was used to divide into 3 groups (n=10):

[0036] The DMSO+normal saline group (NS group) was continuously infused with the same volume of normal saline as remifentanil for 60 minutes;

[0037] DMSO + remifentanil + incision pain group (RI group): 0.1% DMSO was injected intraperitoneally 10 minutes before the injection of remifentanil, and 1 μg·kg of remifentanil was continuously infused by intraperitoneal injection -1 ·min -1 A total of 60 minutes was established, and an incision pain model was established at the same time;

[0038] FRAX597 + remifentanil + incision pain group (F + RI group): 10 min before remifentanil...

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Abstract

The invention discloses an application of a Pak3 inhibitor in treatment of remifentanil induced incision hyperalgesia. Experiments prove that the FRAX597 can be used for inhibiting incision hyperalgesia induced by remifentanil. Therefore, the invention provides a new way for treating remifentanil-induced incision hyperalgesia.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of a Pak3 inhibitor in the treatment of incision hyperalgesia induced by remifentanil. Background technique [0002] Opioids are the most important analgesic drugs for the clinical treatment of acute and chronic pain and cancer pain. The clinical dosage is very large, but they can also activate the pro-nociceptive mechanism in the body while analgesic. Increased responsiveness to stimuli and increased demand for analgesics, ie opioid-induced hyperalgesia (OIH). Remifentanil is an ultra-short-acting μ-opioid receptor agonist, which is widely used in clinical intraoperative analgesia due to its advantages of rapid onset, rapid clearance, no accumulation, and metabolism independent of liver and kidney function. However, the incidence of remifentanil-induced postoperative hyperalgesia (RIH) is much higher than that of other opioid analgesics, up to 85%. Another study found t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P25/00A61P29/00A61K31/519
CPCA61K45/00A61P25/00A61P29/00A61K31/519Y02A50/30
Inventor 李依泽于泳浩谢克亮王国林元元康佳敏
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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