Preparation method of drug-loaded sustained-release stent for resisting osteosarcoma and filling bone defect

A technology for bone defects and osteosarcoma, applied in medical science, prostheses, etc., can solve problems such as failure to promote osteogenesis and untimely repair of bone defects, and achieve the effect of reducing risks, reducing side effects, and promoting osteogenesis

Inactive Publication Date: 2022-07-01
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because it does not promote osteogenesis, the bone defect left after the degradation of the polymer material has not been repaired in time.

Method used

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Embodiment Construction

[0018] The present invention will be described in detail below with reference to the embodiments. The exemplary embodiments and descriptions of the present invention are used to explain the present invention, but are not intended to limit the present invention.

[0019] The invention provides a preparation method of a drug-loaded slow-release stent for filling bone defects against osteosarcoma, which comprises the following steps:

[0020] First, a β-tricalcium phosphate scaffold is prepared, which is a 3D printing method to prepare a β-tricalcium phosphate scaffold. The specific 3D printing preparation technology is the prior art, which will not be repeated here; then the β-tricalcium phosphate scaffold is prepared. The MBG / β-tricalcium phosphate composite scaffold was obtained by immersing in a solution configured by MBG; mesoporous bioactive glass (MBG) is an inorganic material, and its pores are not only conducive to attachment to the β-tricalcium phosphate scaffold, but al...

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Abstract

The invention relates to preparation of a drug-loaded sustained-release stent, in particular to a preparation method of the drug-loaded sustained-release stent for resisting osteosarcoma and filling bone defect, which comprises the following steps: preparing a beta-tricalcium phosphate stent, and immersing the beta-tricalcium phosphate stent into a solution prepared from MBG to obtain an MBG / beta-tricalcium phosphate composite stent; immersing the composite scaffold into a hydrogel solution prepared from chitosan to obtain a composite scaffold attached with the chitosan; and preparing a doxorubicin sustained-release microsphere suspension, and immersing the composite scaffold attached with the chitosan into the suspension to obtain the doxorubicin-loaded sustained-release scaffold. According to the preparation method, adriamycin with good osteosarcoma resistance is loaded on the MBG / beta-tricalcium phosphate composite scaffold, and after the scaffold is implanted, bone defects can be filled, osteogenesis can be promoted, and reconstruction can be accelerated; and the adriamycin can be slowly released in a local space of osteosarcoma resection bone defect, so that the risk of osteosarcoma recurrence is reduced.

Description

technical field [0001] The invention relates to the preparation of a drug-loaded sustained-release stent, in particular to a preparation method of a drug-loaded sustained-release stent used for anti-osteosarcoma to fill bone defects. Background technique [0002] Osteosarcoma is the most common primary malignant bone tumor, and the current treatment is mainly surgical in situ resection + preoperative and postoperative chemotherapy, but the recurrence or bone defect caused by osteosarcoma cannot be avoided. In the clinical process, chemotherapy still needs to be used after the reconstruction of bone defect after local surgery, and patients need to use chemotherapy drugs systemically. At present, drug sustained-release microspheres can well embed drugs, control the release rate of drugs, improve the utilization rate of drugs, and reduce the harm of drugs to the whole body. Therefore, drug-loaded microspheres have been widely studied and applied to the medical field. The comp...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/10A61L27/20A61L27/18A61L27/16A61L27/50A61L27/54
CPCA61L27/12A61L27/10A61L27/20A61L27/18A61L27/16A61L27/50A61L27/54A61L2430/02A61L2300/412A61L2300/416A61L2300/602A61L2300/216A61L2300/236C08L5/08C08L67/04C08L29/04
Inventor 陈世杰曾晋彭毅黄力平王栋仝昭宸李劲松苗惊雷王卫国
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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