Compounds and methods for promoting myelination

A technology of myelin sheath and composition, applied in the field of compounds and methods for promoting myelin sheath formation

Pending Publication Date: 2022-06-24
CASE WESTERN RESERVE UNIV
View PDF26 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Less explored, however, is the hypothesis of enhanced myelination and / or remyelination by endogenous oligodendrocyte precursors or transplanted cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compounds and methods for promoting myelination
  • Compounds and methods for promoting myelination
  • Compounds and methods for promoting myelination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0288] In this example, we show that remyelination is mediated by oligodendrocyte progenitor cells (OPCs), an abundant stem cell population in the CNS and a major source of new myelin-forming oligodendrocytes. Loss of myelin-producing oligodendrocytes in the central nervous system (CNS) underlies many neurological diseases, including multiple sclerosis and a variety of genetic disorders. Using a high-throughput chemical screening approach, we have identified small molecules that promote myelination and functionally enhance remyelination in vivo by stimulating the formation of oligodendrocytes from OPCs. Here, we demonstrate that a broad range of these myelinizing molecules act not through their canonical targets, but through direct inhibition of CYP51, sterol 14-reductase and EBP (a narrow range of enzymes in the cholesterol biosynthetic pathway). We found that chemical or genetic inhibition of these enzymes resulted in the accumulation of Δ8,9-unsaturated sterol intermediates...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present application relates to a method of promoting the production of oligodendrocytes from oligodendrocyte precursor cells by enhancing its survival and / or maturation, comprising administering to the cell an effective amount of an agent that enhances and / or induces the accumulation of [Delta] 8, 9-unsaturated sterol intermediates of the cholesterol biosynthetic pathway in oligodendrocyte precursor cells.

Description

[0001] This application is a division of a Chinese invention patent application (PCT application number PCT / US2017 / 044205) with the application number of 201780059484.9, the invention titled "compounds and methods for promoting myelination" and the application date of July 27, 2017 Application. [0002] Related applications [0003] This application claims priority to US Provisional Application Nos. 62 / 367,416, filed July 27, 2016, and 62 / 452,204, filed January 30, 2017, the subject matter of which is incorporated herein by reference in its entirety. [0004] Government funding [0005] This invention was made with government support under Grant No. R01NS095280 awarded by the National Institutes of Health. The United States Government has certain rights in this invention. Background technique [0006] Multiple sclerosis (MS) is a complex neurological disorder characterized by degeneration of the myelin sheath of the central nervous system (CNS). This insulating substanc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7088A61P25/00A61P25/14A61P25/28A61P25/16A61P25/18
CPCA61K31/7088A61P25/00A61P25/14A61P25/28A61P25/16A61P25/18A61K31/4196A61K31/138A61K31/4174A61K31/4535A61K31/4545A61K31/496A61K31/5375A61K31/198A61K38/16A61K38/215A61K31/137A61K45/06A61K39/3955A61K31/136A61K31/7105C12N9/50C12N15/1137
Inventor P.特萨D.亚当斯Z.胡布勒M.埃利特D.阿利穆图
Owner CASE WESTERN RESERVE UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap