Method and device for establishing mouse chronic constraint stress model

Abstract

The invention discloses an establishment method and an establishment device of a mouse chronic constraint stress model, relates to the field of gastric cancer, and aims to solve the problem that the stress response of chronic constraint to a mouse model is not clear in the prior art. According to the scheme, the binding device comprises a binding box body, and the left side and the right side of the inner wall of the binding box body are jointly and fixedly connected with a first partition plate. By arranging the motor, the first gear, the second gear and the threaded rod, the activity space of the mouse model can be well changed, so that the activity space of the mouse model is well changed, the stress response of chronic constraint to the mouse model is known, and then a quantifiable guidance strategy is provided for implementing psychological intervention treatment; research is carried out by adopting psychological survey, hormone level detection and various molecular biology methods, the research scheme fully embodies tight connection between the foundation and clinical research on the basis of a solid early stage, and a foundation is laid for discovering observability threatening indexes of malignant progression of gastric cancer.

Description

technical field [0001] The invention relates to the field of gastric cancer, in particular to a method and a device for establishing a chronic restraint stress model in mice. Background technique [0002] Gastric cancer is a major challenge to human health, and its morbidity and mortality ranks second among malignant tumors in my country. At present, the clinical treatment of gastric cancer is mainly surgery combined with radiotherapy and chemotherapy. The influence is gradually recognized, especially experimental studies have confirmed that chronic psychological stress can accelerate tumor growth and promote its malignant progression, which makes the urgency of tumor psychotherapy attract more and more attention. It is unclear. Currently, the clinical practice is only in the stage of general psychological support such as health education for patients, and relatively precise intervention treatment cannot be given. This has become a common problem in the field of oncology and p...

AI Technical Summary

Problems solved by technology

[0004] However, the impact of social and psychological factors on the prognosis of cancer patients has attracted increasing attention. Studies have shown that long-term anxiety, depression and other psychological stress stimulate the body's chronic stress can promote the malignant progression of tumors by acting on β2AR, because plexinA1 and β2-AR Chronic stress is relevant in regulating the malignant progression of gastric cancer, and β2-AR affects the EMT of gastric cancer cells by activating the STAT3 signaling pathway, and plexinAl affects the formation of gastric cancer cells by regulating VEGFR2. In summary, a hypothesis is proposed: in patients with gastric cancer, chronic stress can β2-AR / plexinA1 mediates the JAK-STAT3 pathway to affect the ENT and angiogenesis of Zeng cancer cells, thereby promoting the malignant progression of gastric cancer. Chronic stress is common in cancer patients, and it is accompanied by a significant increase in the level of stress-related hormones In the prior art, chronic stress stimulates the secretion of adrenal hormones and acts on the corresponding receptors in the mouse model, and it is relatively lacking to further explore the mechanism of chronic stress to promote the malignant progression of tumors.

Images