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Improved Longqing capsule quality detection method

A technology of Longqing capsules and detection methods, applied in measuring devices, disease resistance to media transmission, instruments, etc., can solve the problem of poor peak shape in the determination of Phellodendron hydrochloride content, inability to effectively control the quality of Longqing capsules, and small Rf values ​​of spots and other problems, to achieve the effect of good peak shape, qualified resolution, and short peak extraction time

Pending Publication Date: 2022-05-27
贵州远程制药有限责任公司
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

But in the actual detection, it is found that the detection method has the following defects: (1) the main spot for identification of Coptidis Rhizoma and Cortex Phellodendron thin layer is blurred, the spot Rf value is on the small side, and the problem of poor reproducibility; (2) the content determination peak of Cortex Phellodendri Hydrochloride The quality of Longqing Capsules cannot be effectively controlled due to the problems of poor shape, poor resolution, and long peak eluting time; (3) The TLC identification of Patrinia and Alisma is not involved in the original test content; (4) The content determination of 23-acetyl alisol B and 23-acetyl alisol C was not involved in the original test content

Method used

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  • Improved Longqing capsule quality detection method
  • Improved Longqing capsule quality detection method
  • Improved Longqing capsule quality detection method

Examples

Experimental program
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Effect test

Embodiment 1

[0043] [Prescription] Alisma 261g, Plantago 52.5g, Papaya 522g, Honeysuckle 261g, Cortex Moutan 261g, Hedyotis diffusa 522g, Red Peony 261g, Agrimony 261g, Coptis chinensis 261g, Cork 261g.

[0044] [Preparation method] For the above ten flavors, Alisma is crushed into fine powder, sieved, and set aside; honeysuckle, sorrel, Hedyotis diffusa, Agrimony are boiled twice with water for 1 hour each time, combined with the decoction, and filtered , the filtrate was concentrated to a clear paste with a relative density of 1.25-1.30 at 50 °C; the other five flavors such as psyllium were heated and refluxed with 60% ethanol to extract three times, the first time was 3 hours, the second time was 2 hours, and the third time was 1 hour. Combine the extracts, filter, recover ethanol from the filtrate, and concentrate to a clear paste with a relative density of 1.25 to 1.30 at 50°C; combine the above clear pastes, add Alisma orientalis fine powder, mix well, dry at 65°C under reduced pressu...

Embodiment 2

[0064] [Prescription] Alisma 261g, Plantago 52.5g, Papaya 522g, Honeysuckle 261g, Cortex Moutan 261g, Hedyotis diffusa 522g, Red Peony 261g, Agrimony 261g, Coptis chinensis 261g, Cork 261g.

[0065] [Preparation method] For the above ten flavors, Alisma is crushed into fine powder, sieved, and set aside; honeysuckle, sorrel, Hedyotis diffusa, Agrimony are boiled twice with water for 1 hour each time, combined with the decoction, and filtered , the filtrate was concentrated to a clear paste with a relative density of 1.25-1.30 at 50 °C; the other five flavors such as psyllium were heated and refluxed with 60% ethanol to extract three times, the first time was 3 hours, the second time was 2 hours, and the third time was 1 hour. Combine the extracts, filter, recover ethanol from the filtrate, and concentrate to a clear paste with a relative density of 1.25 to 1.30 at 50°C; combine the above clear pastes, add Alisma orientalis fine powder, mix well, dry at 65°C under reduced pressu...

Embodiment 3

[0092] [Prescription] Alisma 261g, Plantago 52.5g, Papaya 522g, Honeysuckle 261g, Cortex Moutan 261g, Hedyotis diffusa 522g, Red Peony 261g, Agrimony 261g, Coptis chinensis 261g, Cork 261g.

[0093] [Preparation method] For the above ten flavors, Alisma is crushed into fine powder, sieved, and set aside; honeysuckle, sorrel, Hedyotis diffusa, Agrimony are boiled twice with water for 1 hour each time, combined with the decoction, and filtered , the filtrate was concentrated to a clear paste with a relative density of 1.25-1.30 at 50 °C; the other five flavors such as psyllium were heated and refluxed with 60% ethanol to extract three times, the first time was 3 hours, the second time was 2 hours, and the third time was 1 hour. Combine the extracts, filter, recover ethanol from the filtrate, and concentrate to a clear paste with a relative density of 1.25 to 1.30 at 50°C; combine the above clear pastes, add Alisma orientalis fine powder, mix well, dry at 65°C under reduced pressu...

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Abstract

The invention relates to an improved Longqing capsule quality detection method. The detection method comprises the following steps: carrying out thin-layer identification inspection on coptis chinensis, cortex phellodendri, patrinia herb and rhizoma alismatis medicinal materials in a capsule, and determining the contents of phellodendrine hydrochloride, 23-acetyl alisol B and 23-acetyl alisol C in the capsule. Through methodological investigation, the detection method has the effects of being high in specificity, good in durability and good in repeatability, the quality condition of the Longqing capsules can be effectively detected, and the product quality is further improved.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to an improved Longqing capsule quality detection method. Background technique [0002] Longqing Capsule, a product of Guizhou Long-range Pharmaceutical Co., Ltd., has the functions of clearing away heat and detoxifying, cooling blood and dispelling stranguria. It is used for hot stranguria caused by damp-heat in the Lower Jiao, and symptoms include frequent urination, urgency, dysuria, short urination, low back pain, and abdominal distention. [0003] Longqing Capsule is included in the 2020 edition of the "Chinese Pharmacopoeia", and the detection contents are: traits; microscopic identification; Coptis chinensis and Cortex Phellodendri thin layer identification; Peony flower thin layer identification; honeysuckle thin layer identification; red peony thin layer identification; inspection; Determination of Berberine Hydrochloride; Determination of Phellodendron Hydrochloride. But in...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/95
CPCG01N30/90G01N30/95Y02A50/30
Inventor 程吉祥吴军王福勇穆启翔鲁杰冉从姣
Owner 贵州远程制药有限责任公司
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