Application of heat shock protein HSP90 inhibitor-tanspiramycin in preparation of medicine for resisting grass carp reovirus

Abstract

The invention discloses an application of a heat shock protein HSP90 inhibitor-tanspiramycin in preparation of a medicine for resisting grass carp reoviruses, and particularly relates to an application of the heat shock protein HSP90 inhibitor-tanspiramycin in inhibition of binding of the grass carp reoviruses to cell surfaces and invasion of the grass carp reoviruses. In-vitro cell experiments prove that the heat shock protein HSP90 inhibitor-tanspiramycin has the effect of resisting GCRV (Growth Factor Receptor Virus); the action mode is that the GCRV capsid protein is prevented from being combined with a cell surface receptor, so that the virus is inhibited from entering cells, and the antiviral effect is achieved. In addition, the 17-AAG is found to have the function of resisting GCRV infection of the grass carp for the first time, and a potential strategy is provided for preventing or treating GCRV infection of the grass carp.

Description

Technical field [0001] The present invention relates to the field of medicinal uses, in particular, the application of heat-stimulatin HSP90 inhibitor - terspiromycin in the preparation of anti-grass carp reovirus drugs. Background [0002] Grass carp has always been the first aquaculture species in China, grass carp hemorrhage caused by grass carp reovirus (GCRV) every year to grass carp aquaculture industry brings huge economic losses, the disease has a strict temperature dependence, the incidence cycle is obvious, generally in the spring and autumn, the water temperature at 25 ° C when the disease, there is no drug for the disease on the market. [0003] Grass carp reovirus (GCRV) has similar morphological structural characteristics with orthoptovirus, is a double-stranded RNA virus of the icosahedron, with a diameter of about 70 nm, a viral core diameter of about 50 nm, no capsule membrane, the outermost layer is 7 capsid proteins (VP1-VP7), responsible for viral infestation,...

AI Technical Summary

Problems solved by technology

[0002] Grass carp has always been the top aquaculture species in my country. Grass carp hemorrhagic disease caused by grass carp reovirus (GCRV) brings huge economic losses to the grass carp aquaculture industry every year. The disease has a strict temperature dependence, and the disease cycle is obvious. Generally, in spring and autumn, when the water temperature is 25°C, the onset occurs. There is no drug for this disease on the market.

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