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Device and method for measuring brain activity

A technology of brain activity and brain electrical activity, which is used in diagnostic recording/measurement, application, medical science, etc.

Pending Publication Date: 2022-05-17
CORTICAL DYNAMICS
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  • Abstract
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Problems solved by technology

[0007] Despite the convenience of routine means of measuring or monitoring brain activity based on neurophysical modeling techniques, there is still room for improvement

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  • Device and method for measuring brain activity
  • Device and method for measuring brain activity
  • Device and method for measuring brain activity

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Embodiment Construction

[0074] overview

[0075] There is an important clinical need to be able to measure brain activity of a subject, especially in real time during medical interventions such as surgery, and to be able to monitor anesthesia levels during surgery. Features of EEG signals from human individuals are related to their brain activity. For example, alpha rhythm is a defining feature of resting EEG signals in humans and has played a central role in the phenomenological description of brain electromagnetic activity during cognition. The macroscopic approach for assessing brain function via representation of EEG features such as alpha rhythm (referred to herein as "neurophysical assessment") is based on neural population models. Typically, neural population model parameters are determined by iterative tuning methods, where the best parameters are selected from the tuning set as the model produces (or "predicts") EEG signals exhibiting specific features of the observed EEG signals (e.g., spe...

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Abstract

A computer-implemented method for measuring brain activity of a subject, the method comprising: receiving electroencephalogram (EEG) data representing electroencephalogram measurements of brain electrical activity of the subject; and fitting a parameter of the neural population model to the EEG data to determine a respective value of the parameter, the respective value of the parameter comprising one or more values of an inhibitory post synaptic potential rate constant (gammai), where gammai represents a state of brain responsiveness, an increase in gammai relative to a reference value indicates an enhanced state of brain responsiveness, and an increase in gammai relative to a reference value indicates an enhanced state of brain responsiveness. And a decrease in [gamma] i relative to the reference value indicates a decrease in the state of brain responsiveness.

Description

technical field [0001] The present invention relates to devices and methods for measuring brain activity based on electroencephalography (EEG) signals. Background technique [0002] Electrical activity in the brain is the result of the flow of electrical charge caused by neuronal activity, and varies in distinctive patterns (such as "waves") across adjacent brain regions in response to stimuli. The overall synchronized activity of neurons in the human brain can be recorded using electroencephalography (EEG), which involves using electrodes to measure electrical potentials on the outside of an individual's scalp (and thus infer neuronal function). [0003] EEG provides a simple and non-invasive way to study brain activity based on specific features that appear in the signal output. EEG signals typically contain rhythmic features that occur in specific frequency bands, including those known in the art as the alpha, beta, theta, and delta bands. Alpha rhythmic signatures have...

Claims

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Application Information

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IPC IPC(8): A61B5/374A61B5/00
CPCA61B5/7239A61B5/7267A61B5/7275A61B5/7225A61B5/372A61B5/279A61B5/291A61B5/4821A61B2505/05A61B5/4839A61B5/369
Inventor 大卫·蒂博尔·朱利安·利列伊
Owner CORTICAL DYNAMICS
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