Inhibitor for regulating breast cancer proliferation and migration based on SREBP-1/PI3K/AKT signal channel and application thereof

A signaling pathway and inhibitor technology, applied in the field of biomedicine, can solve the problems of high heterogeneity of breast cancer, arduous treatment tasks, and treatment limitations, and achieve high selectivity, inhibition of breast cancer proliferation and migration, and good effects.

Active Publication Date: 2022-05-13
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Nevertheless, the treatment of breast cancer is limited due to its high heterogeneity, drug resistance, metastasis, etc., and its treatment task is still arduous.

Method used

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  • Inhibitor for regulating breast cancer proliferation and migration based on SREBP-1/PI3K/AKT signal channel and application thereof
  • Inhibitor for regulating breast cancer proliferation and migration based on SREBP-1/PI3K/AKT signal channel and application thereof

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Embodiment 1

[0023] In the present invention, based on the existing 6-peptide library, the Cell Counting Kit-8 method is used to initially screen whether the short peptide has an inhibitory effect on the proliferation of breast cancer cells, thereby preliminarily determining that the short peptide sequence is Val-Trp-Arg-Arg-His- Phe. The short peptide sequence was submitted to Shanghai Sangong for solid-phase synthesis, and the synthesized short peptide was subjected to the following experiments to confirm that it can regulate the proliferation and migration of breast cancer by inhibiting the SREBP-1 / PI3K / AKT signaling pathway.

[0024] The data in this study were processed and analyzed using SPSS 22.0 statistical software, and the count data were expressed as mean ± standard deviation (%), the comparison between two groups was carried out by / test, the comparison between multiple groups was carried out by one-way analysis of variance, and the pairwise comparison between groups was carrie...

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Abstract

The invention relates to an inhibitor for regulating breast cancer proliferation and migration based on an SREBP-1 / PI3K / AKT signal pathway and application of the inhibitor, the inhibitor is a short peptide, and the short peptide has an amino acid sequence as shown in SEQ ID NO.1. The inhibitor disclosed by the invention can be generated by adopting an existing short peptide synthesis technology, and is low in cost, good in effect, high in safety and high in selectivity.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to an inhibitor for regulating the proliferation and migration of breast cancer based on inhibiting the SREBP-1 / PI3K / AKT signaling pathway and its application. Background technique [0002] Breast cancer is the most common female malignant tumor. The incidence of breast cancer in the world has been on the rise since the late 1970s. One of eight women in the United States will suffer from breast cancer in their lifetime. In the treatment of breast cancer, surgery is still the main means of treatment of breast cancer, chemotherapy, radiotherapy and endocrine therapy as adjuvant therapy. With the in-depth research on breast cancer, the treatment methods have become more and more diversified, and the curative effect of patients has also improved. Nevertheless, the treatment of breast cancer is limited due to its high heterogeneity, drug resistance, metastasis and other r...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61P35/00A61P35/04C07K7/06
CPCA61K38/08A61P35/00A61P35/04C07K7/06
Inventor 李萍王莹王楠
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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