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Dentificial composition for treating dental biofilms

A composition and dentifrice technology, applied in the field of dentifrice compositions, can solve problems such as unpleasant organ sensation, astringency, etc., and achieve the effects of helping enamel remineralization cycle, reducing astringency, and good sensory experience

Pending Publication Date: 2022-05-10
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another problem with formulating zinc-containing dentifrices is astringency, an organoleptically unpleasant effect on zinc ions

Method used

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  • Dentificial composition for treating dental biofilms
  • Dentificial composition for treating dental biofilms
  • Dentificial composition for treating dental biofilms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0088] Example A: Examples 1 to 5

Embodiment 1

[0089] Example 1 is a reference to a phosphate buffered saline solution, while Examples 2 to 5 are dentifrice compositions. They can be suitably prepared by conventional methods selected by the formulator. Examples 2 and 4 are comparative formulations, whereas Examples 3 and 5 are inventive formulations according to the invention. Examples 3 and 5 were made with fluoride ion source, zinc ion source (zinc citrate or zinc lactate) and glycine, respectively. In parallel, comparative formulation examples 2 and 4 were prepared without glycine. All compositions were prepared from mixtures of the ingredients in Table 1 in the ratios indicated.

[0090] Table 1: Examples 1 to 5

[0091]

Embodiment B

[0092] Example B: Assays for Measuring Biofilm Architecture, Penetration of Antimicrobial Agents, and Endotoxin Neutralization in Biofilms

[0093] For inventive dentifrice compositions of the present invention and controls, in situ plaque biofilms the following assays were used in order to: (1) Biofilm EPS matrix destabilization was assessed by measuring fluorescence emitted from labeled EPS biofilms and the thickness of the dental biofilm; and (2) assessing the penetration efficiency of zinc ions to bacteria by measuring the percentage of colocalization.

[0094] The details of the assay are described below.

[0095] (a) Substrate for biofilm growth

[0096] Hydroxyapatite ("HA") disks were used for in situ growth of biofilms. The HA discs were designed with three parallel grooves in each disc (ie 200 μm wide for the side grooves; 200 μm deep; and 500 μm wide and 500 μm deep for the middle groove). When attaching the disc to the subject's mouth, keep these grooves ver...

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Abstract

A dentifrice composition is provided comprising a source of zinc ions, glycine and fluoride ions, particularly in the absence of a source of stannous ions, for the treatment of dental plaque biofilms.

Description

technical field [0001] The present invention relates to dentifrice compositions having improved efficacy in helping to inhibit biofilm formation or helping to disrupt biofilm. Background technique [0002] Dental plaque (also known as dental biofilm) is a sticky, colorless deposit of bacteria that continually forms on tooth surfaces. Dental plaque is usually composed of bacteria and extracellular polymeric substances (so-called "EPS"). EPS is a biopolymer derived from microorganisms in which biofilm microorganisms are embedded. J. Bacteriol. 2007, 189(22): 7945. Saliva, food, and fluids combine to create these deposits, which collect where the teeth and gums meet. Plaque buildup is a major contributor to poor oral health, which can lead to dental caries and periodontal (gum) disease, including gingivitis. One way in which dentifrice compositions can help prevent and control plaque is through the use of antimicrobial agents such as sources of zinc ions. A disadvantage or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/21A61K8/27A61K8/44A61Q11/00
CPCA61K8/21A61K8/27A61K8/44A61K2800/30A61K2800/48A61Q11/00A61K8/365A61K8/19A61K8/25
Inventor R·斯特兰德李潇潇史运明
Owner PROCTER & GAMBLE CO
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