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Extraction test device for treating rheumatoid arthritis based on deoxyinosine

A deoxyinosine, rheumatoid technology, applied in the direction of anti-inflammatory agents, organic active ingredients, non-central analgesics, etc., can solve the problems of large side effects, expensive biological preparations, many adverse reactions, etc., to relieve local symptoms Effect

Pending Publication Date: 2022-04-12
THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

[0006] In order to solve the problems raised in the above-mentioned background technology, the object of the present invention is to provide an extraction test device for treating rheumatoid arthritis based on deoxyinosine, which has verified that deoxyinosine has the effect of preventing or treating rheumatoid arthritis. , which provides the advantages of a new direction for the research and development of anti-rheumatic drugs, and solves the problems that the existing drugs for the treatment of rheumatoid arthritis generally have large side effects, many adverse reactions, and some biological agents are extremely expensive, which is unbearable for most patients

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  • Extraction test device for treating rheumatoid arthritis based on deoxyinosine
  • Extraction test device for treating rheumatoid arthritis based on deoxyinosine

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Embodiment Construction

[0013] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0014] Such as Figure 1 to Figure 2 As shown, an extraction test device based on deoxyinosine for the treatment of rheumatoid arthritis includes a deoxyinosine extraction unit and a deoxyinosine test unit. The deoxyinosine extraction unit includes a plasma collection module, a high-resolution liquid mass spectrometer , Simca-p software, comparison module and compound database. The plasma collection module includes healthy plasma and RA patient plasma. The hig...

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Abstract

The invention discloses an extraction test device for treating rheumatoid arthritis based on deoxyinosine, which comprises a deoxyinosine extraction unit and a deoxyinosine test unit, and the deoxyinosine extraction unit comprises a plasma collection module, a high-resolution liquid chromatograph-mass spectrometer, Simca-p software, a comparison module and a compound database. According to the application, metabolite deoxyinosine (DI) with significant difference is screened out through plasma non-targeted metabonomics, the treatment effect of the deoxyinosine in rheumatoid arthritis is verified, an endogenous small molecule substance-deoxyinosine (DI) is screened out from RA plasma non-targeted metabonomics, and the application has the advantages that the effect of the DI in treating rheumatoid arthritis is verified; cell and animal experiments prove that DI can relieve local symptoms of mice with rheumatoid arthritis by inhibiting inflammatory response of the body, and a new direction is provided for research and development of anti-rheumatism drugs. The DI is expected to become a safer medicine for treating rheumatoid arthritis.

Description

technical field [0001] The invention relates to the technical field of rheumatoid arthritis, in particular to an extraction test device for treating rheumatoid arthritis based on deoxyinosine. Background technique [0002] Rheumatoid arthritis (RA) is a common autoimmune disease. Patients clinically present with persistent synovitis in the peripheral joints, eventually leading to cartilage erosion and bone destruction. Rheumatoid arthritis can occur in any age group, the global incidence rate is 0.5%-1%, the incidence rate in my country is 0.42%, and the male to female prevalence ratio is about 1:4. If RA patients cannot receive timely and effective treatment, their condition will gradually worsen, eventually leading to joint deformity, dysfunction, and even disability, which will affect the daily life ability of patients and bring huge economic burden to patients' families and society. [0003] The main purpose of rheumatoid arthritis treatment is to reduce joint inflamma...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/708A61P19/02A61P29/00C07H19/173
Inventor 徐得莱苏存锦潘杰汤柳星施爱明
Owner THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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