Application of histone deacetylase inhibitor in preparation of medicine for treating heart disease
A deacetylase and histone technology, which can be used in drug combinations, cardiovascular system diseases, pharmaceutical formulations, etc., can solve the lack of treatment methods, and has not yet seen histone deacetylase inhibitors in the treatment of heart disease and DMD deficiency. Cardiomyopathy, etc.
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[0052] The present invention will be further described below in conjunction with embodiment. However, the scope of the present invention is not limited to the following examples. Those skilled in the art can understand that various changes and modifications can be made in the present invention without departing from the spirit and scope of the present invention.
[0053] The instruments, reagents, materials, etc. involved in the following examples, unless otherwise specified, are conventional instruments, reagents, materials, etc. in the prior art, and can be obtained through formal commercial channels. The experimental methods, detection methods, etc. involved in the following examples, unless otherwise specified, are conventional experimental methods, detection methods, etc. in the prior art.
[0054] Experiment 1 Construction and study of CDK13 myocardial induced deletion mouse model
[0055] (1) Construction of CDK13 knockout mouse model: exon 3 (exon3) and exon 4 (exon4...
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