Composition of tinidazole suppository as well as preparation method and application of composition
A technology of tinidazole suppository and composition, which is applied in the field of medicine, can solve the problems of slow onset of action and inconvenient treatment, and achieve the effects of stable properties, large specific surface area, and stable melting time limit
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Embodiment 1
[0030] A composition of tinidazole suppositories, each tinidazole suppository contains the following components and parts by weight, 10nm nano tinidazole 0.4g, 36 type mixed fatty acid glycerides 1g, clindamycin hydrochloride 0.05g, Fluconazole 0.1g, surface functionalized nano-zinc oxide 0.05g, 20nm nano-chitosan 0.1g, polydimethyldiallylammonium chloride containing octadecyl hydrophobic group 0.1g, boric acid 0.1g, micro Crystalline cellulose starch sodium glycolate 0.05g.
[0031] Nano chitosan is the composition of 0.05g nano carboxymethyl chitosan and 0.05g nano pegylated chitosan, the particle diameter of nano carboxymethyl chitosan and nano pegylated chitosan particles are both 20nm.
[0032] The specific surface area of the surface functionalized nano zinc oxide particles is 10m 2 / g, the particle diameter of this particle is 20nm, the preparation method of the nano-zinc oxide of surface functionalization comprises the following steps: dissolving rosin in isopropano...
Embodiment 2
[0038] A composition of tinidazole suppositories, each tinidazole suppository contains the following components and parts by weight, 15nm nano tinidazole 0.6g, 36 type mixed fatty acid glycerides 1.3g, clindamycin hydrochloride 0.08g , fluconazole 0.15g, surface functionalized nano-zinc oxide 0.08g, 25nm nano-chitosan 0.15g, polydimethyldiallylammonium chloride containing octadecyl hydrophobic group 0.15g, boric acid 0.15g, Sodium microcrystalline cellulose starch glycolate 0.06g.
[0039] Nano-chitosan is a composition of 0.06g nanometer carboxymethyl chitosan and 0.08g nanometer PEGylated chitosan, and the particle diameters of nanometer carboxymethyl chitosan and nanometer PEGylated chitosan particles are both 25nm.
[0040] The specific surface area of the surface functionalized nano zinc oxide particles is 100m 2 / g, the particle diameter of this particle is 23nm, the preparation method of the nano-zinc oxide of surface functionalization comprises the steps: dissolvin...
Embodiment 3
[0046] A composition of tinidazole suppository, each tinidazole suppository contains the following components and parts by weight, 20nm nano tinidazole 0.8g, 36 type mixed fatty acid glyceride 1.5g, clindamycin hydrochloride 0.1g , fluconazole 0.2g, surface functionalized nano-zinc oxide 0.1g, 30nm nano-chitosan 0.2g, polydimethyldiallylammonium chloride containing octadecyl hydrophobic group 0.2g, boric acid 0.2g, Sodium microcrystalline cellulose starch glycolate 0.07g.
[0047] Nano-chitosan is a composition of 0.08g nanometer carboxymethyl chitosan and 0.12g nanometer pegylated chitosan, and the particle diameters of nanometer carboxymethyl chitosan and nanometer pegylated chitosan particles are both 30nm.
[0048] The specific surface area of the surface functionalized nano zinc oxide particles is 200m 2 / g, the particle diameter of this particle is 25nm, the preparation method of the nano-zinc oxide of surface functionalization comprises the steps: dissolving rosin i...
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