Full-automatic solid-phase organic synthesis modular equipment

Abstract

The invention discloses full-automatic solid-phase organic synthesis modular equipment which is composed of an external frame, the reactor module, the reaction reagent preparation module, the first solvent module, the second solvent module, the valve module, the electronic device module, the equipment control and data recording module, the gas and temperature adjusting module, the waste liquid collecting module and the connecting pipeline are arranged in the outer frame. The solid-phase organic synthesis device has the characteristics of simplicity and stability in operation, wide application range, easiness in module disassembly and replacement, high automation degree and capability of completing various solid-phase organic synthesis reactions.

Description

technical field [0001] The invention relates to the field of solid-phase organic synthesis equipment, in particular to a fully automatic solid-phase organic synthesis modular equipment. Background technique [0002] In 1963, the famous American biochemist Bruce Merrifield first proposed the solid-phase peptide synthesis method (SPPS). In 1966, he invented the first automatic solid-phase peptide synthesizer based on his own concept, which was used in the mass production of peptides. It uses nitrogen bubbles to stir the reactants, and consists of a reactor unit and a control unit. Computer program control to achieve limited automatic synthesis, becoming the first generation of peptide synthesizer. Although it has obvious defects in the stirring method and other functions, it liberates people from the laboratory after all and promotes the automation of peptide synthesis. This synthetic method, which is a milestone in peptide chemistry, has become the preferred method for pept...

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Problems solved by technology

[0006] Therefore, the solid-phase synthesis devices currently on the market are difficult to meet the new requirements of different types of solid-phase organic synthesis, and mainly have the following defects: 1. The solid-phase synthesis devices currently on the market are mainly for synthesizing polypeptide products, and their reactions are mainly Forming amide bonds, there is no corresponding functional setting for other chemical bonds such as ester bonds, hydroxyl groups, disulfide bonds, phosphite bonds, 5' hydroxyl coupling of oligonucleotides, which limits its use in other solid-phase organic synthesis 2. Currently, the solid-phase synthesis devices sold in the market are either small-scale or pilot-scale, and there is no one that can meet the requirements of small-scale scale and can be applied to pilot-scale production equipment; 3 , The solid-phase synthesis devices currently on the market have almost no corresponding temperature control for the reaction temperature, pre-dissolved reaction liquid temperature, and washing liquid temperature, resulting in limited application in solid-phase peptide and organic synthesis. For chemical reactions with harsh conditions unable to carry out

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