Application of kinase inhibitor in preparation of male contraceptive or product

A kinase inhibitor and inhibitor technology are applied in the application field of the kinase inhibitor in the preparation of male contraceptive drugs or products, which can solve the problems of inability to guarantee the contraceptive rate of condoms, reduce the quality of sexual life, complicated bleeding and the like, and achieve sexual life. The effect of not reducing the quality and inhibiting the formation of sperm

Active Publication Date: 2022-01-14
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have shown that the contraceptive rate of condoms cannot be guaranteed to be 100%, and it will reduce the quality of sexual life; while vasectomy is an invasive method, there is a risk of concurrent bleeding after surgery, and there are many disadvantages
In addition, if the vasectomy patient wishes to restore fertility, surgery is required to recanalize the vas deferens, which increases the risk

Method used

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  • Application of kinase inhibitor in preparation of male contraceptive or product
  • Application of kinase inhibitor in preparation of male contraceptive or product
  • Application of kinase inhibitor in preparation of male contraceptive or product

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Embodiment Construction

[0022] In order to make the purpose, technical solution and advantages of the present application clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0023] The inventors of the present application have speculated that the intraperitoneal injection of small molecule kinase inhibitors can target the kinases of spermatogenic cells and inhibit the formation of spermatozoa to achieve reversible contraception. This kinase inhibitor is expected to provide a new method for male contraception and contribute to the development of reproductive medicine. play a positive role.

[0024] Specifically, in order to verify its influence on the germ cells and the organisms where the germ cells are located, the present application has carried out the following implementation process.

[0...

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Abstract

The invention relates to an application of a kinase inhibitor in preparation of a male contraceptive or a product, and the inhibitor is at least one of N-[2-(3, 4-dihydro-3-oxo-2-quinoxalinyl)-4-(1-methyl ethyl) phenyl]-2-thiophenecarboxamide, a pharmaceutically acceptable salt thereof, a solvate thereof and a solvate of the pharmaceutically acceptable salt of the N-[2-(3, 4-dihydro-3-oxo-2-quinoxalinyl)-4-(1-methyl ethyl) phenyl]-2-thiophenecarboxamide. The kinase inhibitor can reduce the sperm concentration in the epididymis tail so as to inhibit sperm formation, and does not affect spermatogonium. After drug withdrawal, sperm formation can recover to the level before drug administration, and reversible contraception is achieved. Compared with the existing male contraceptive for inhibiting the generation of testosterone, the kinase inhibitor does not influence the synthesis of male hormones such as testosterone, so that the male sexual characteristics are not changed, and the quality of sexual life is not reduced.

Description

technical field [0001] The application relates to the technical field of application of kinase inhibitors, in particular to the application of kinase inhibitors in the preparation of male contraceptive medicines or products. Background technique [0002] In the prior art, male contraceptive methods generally include condoms and vasectomy. Studies have shown that the contraceptive rate of condoms cannot be guaranteed to be 100%, and it will reduce the quality of sexual life; while vasectomy is an invasive method, and there is a risk of concurrent bleeding after surgery, which has many disadvantages. In addition, if a vasectomy patient wishes to restore fertility, surgery is required to recanalize the vas deferens, which increases the risk. Therefore, there is an urgent need for an efficient, safe, simple, and non-invasive reversible contraceptive method for males. Contents of the invention [0003] Asthenozoospermia is one of the common causes of male infertility, and the...

Claims

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Application Information

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IPC IPC(8): A61K31/498A61P15/16
CPCA61K31/498A61P15/16
Inventor 李怀标蔡英李娜王骁
Owner HUAZHONG UNIV OF SCI & TECH
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