Preparation method of 9-aryl xanthene compounds

Abstract

The invention discloses a novel preparation method of 9-aryl xanthene compounds, xanthene compounds are subjected to C (sp3)-H arylation reaction with aromatic hydrocarbon in a free radical process to prepare a series of 9-aryl xanthene compounds. Compared with the prior art, the method has the remarkable advantages that traditional severe reaction conditions such as a transition metal catalyst, an oxidizing agent and high temperature are not needed, and the method has the advantages of mild reaction conditions, wide substrate application range, good atom economy and convenient reaction operation.

Description

technical field [0001] The application belongs to the technical field of organic synthesis, and in particular relates to a preparation method of 9-aryl xanthene compounds. Background technique [0002] Xanthenes are important structural units in organic synthesis, and are also the backbone structures of many important molecules such as drugs, catalysts and fluorescent dyes. Based on the wide application of xanthene compounds, the method of synthesizing functionalized xanthene compounds is particularly important. [0003] The traditional method of synthesizing xanthene compounds is often based on the arylation reaction of the benzylic position, usually using halogenated aromatic hydrocarbons as precursors, which can be carried out smoothly under the catalysis of palladium or nickel. For example, Walsh’s research group reported the C(sp 3 )-H arylation reaction, synthesis of triarylmethane compounds under palladium or nickel catalysis However, other methods for synthesizin...

AI Technical Summary

Problems solved by technology

In the present invention, an efficient and mild electrochemical synthesis strategy is proposed, in which xanthenes undergo C(sp 3 )-H arylation reaction, a series of 9-aryl xanthene compounds are conveniently prepared, which overcomes the harsh conditions such as the use of oxidants, noble metal catalysts and high temperatures in the traditional synthesis methods of the prior art

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