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Application of Perifosine to preparation of anti-Hantaan virus drug

A technology of perifosine and 1. perifosine is applied in the application field of preparing anti-Hantaan virus drugs, can solve problems such as non-specific therapeutic drugs, and achieve the effects of inhibiting proliferation, inhibiting replication and reducing viral load

Active Publication Date: 2021-12-21
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, although a lot of research work has been done on Hantaan virus infection, there is no specific treatment drug, and the main clinical treatment is still supportive care. Therefore, it is extremely important to develop anti-Hantan virus drugs with high efficiency and low toxicity important clinical significance

Method used

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  • Application of Perifosine to preparation of anti-Hantaan virus drug
  • Application of Perifosine to preparation of anti-Hantaan virus drug
  • Application of Perifosine to preparation of anti-Hantaan virus drug

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Embodiment Construction

[0018] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the associated drawings. Preferred embodiments of the invention are shown in the accompanying drawings. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0019] The present invention relates to the medicine application of a kind of compound, and this compound is Perifosine (KRX-0401, perifosine), and the structure is:

[0020]

[0021] The invention relates to the application of the compound in the preparation of anti-Hantaan virus drugs. Experiments prove that the compound can effectively inhibit the replication and proliferation of Hantaan virus, and can be used for the preparation of drugs for treating he...

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Abstract

The invention relates to an application of Perifosine to preparation of an anti-Hantaan virus drug. At present, no specific treatment drug aiming at a Hantaan virus infection exists, and the main clinical treatment means are still mainly supportive treatment, so that the research and development of the efficient and low-toxicity anti-Hantaan virus drug have extremely important clinical significance. The invention relates to application of the Perifosine to preparation of the anti-Hantaan virus drug, and the Perifosine is used for inhibiting replication and proliferation of Hantaan viruses. It is proved by experiments that after the Perifosine is added, a virus load in an infected cell is obviously reduced, a nucleic acid level is obviously reduced, and the compound has small influence on the cell activity under the concentration of playing an anti-virus effect and can be used as a high-efficiency and low-toxicity anti-Hantaan virus drug.

Description

technical field [0001] The invention relates to the pharmaceutical application of a compound, in particular to the application of Perifosine in the preparation of anti-Hantaan virus medicine. Background technique [0002] Hantaan virus (Hantaan virus, HTNV) belongs to the genus Orthohantaanvirus of the family Hantaanviridae of the order Bunyaviridae, and is a single-stranded negative-strand RNA virus. , which encode viral RNA-dependent RNA polymerase (RdRp or L protein), envelope glycoproteins Gn and Gc, and viral nucleocapsid protein NP, respectively. In 1976, Korean scholar Lee Ho-wang successfully isolated the virus for the first time from the lung tissue of Apodemus spp. in the Hantan River Basin of the country. The replication mechanism of HTNV is still unclear. [0003] Hantaan virus is the main pathogen that causes Hemorrhagic fever with renal syndrome (HFRS) in my country. HFRS is an acute viral infectious disease transmitted by rodents. The virus is highly contagi...

Claims

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Application Information

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IPC IPC(8): A61K31/675A61P31/14
CPCA61K31/675A61P31/14Y02A50/30
Inventor 吴兴安王芳李洲朋张晓晓应旗康董宇航冯禹楠
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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