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Application of immunogenic cell death-related gene in survival prognosis and radiotherapy responsiveness of head and neck squamous carcinoma

An immunogenic, cell death technique with applications in disease prognosis and molecular biology

Active Publication Date: 2021-11-26
SHANDONG UNIV QILU HOSPITAL
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Problems solved by technology

However, at present, there are still few studies on the role of immunogenic cell death-related genes in head and neck squamous cell carcinoma. Therefore, it is necessary to explore the relationship between immunogenic cell death-related genes and head and neck squamous cell carcinoma. Laying the foundation for the diagnosis and prognosis of squamous cell carcinoma

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  • Application of immunogenic cell death-related gene in survival prognosis and radiotherapy responsiveness of head and neck squamous carcinoma
  • Application of immunogenic cell death-related gene in survival prognosis and radiotherapy responsiveness of head and neck squamous carcinoma
  • Application of immunogenic cell death-related gene in survival prognosis and radiotherapy responsiveness of head and neck squamous carcinoma

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Experimental program
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Embodiment

[0067] experimental method

[0068] 1. Research proposal

[0069] For the technical framework of differential gene screening and index construction, see Figure 4 .

[0070] 2. Head and neck cancer patient cohort public data and immunogenic cell death-related genes download

[0071] Head and neck cancer clinicopathological information and RNA-seq data from the TCGA database ( https: / / portal.gdc.cancer.gov / )download. Using "pyroptosis", "apoptosis", and "autophagy" as keywords respectively from the GO database ( http: / / amigo.geneontology.org / amigo / landing ) to obtain 666 immunogenic cell death-related genes.

[0072] 3. Construction of immunogenic cell death-related genetic prognostic index (ICDRGPI)

[0073] From 528 patients with head and neck cancer, patients with previous history of malignant tumors, history of radiotherapy and chemotherapy, non-squamous cell carcinoma and no survival information were excluded, and 451 patients with primary head and neck squamou...

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Abstract

The invention provides application of an immunogenic cell death-related gene in survival prognosis and radiotherapy responsiveness of head and neck squamous carcinoma, and belongs to the technical field of disease prognosis and molecular biology. According to the application, the immunogenic cell death-related gene prognostic index (ICDRGPI) is constructed by screening the head and neck squamous carcinoma prognosis-related gene, and the ICDRGPI is proved to have a good prediction effect on the survival of head and neck squamous carcinoma patients; and the survival of the ICDRGPI is obviously different from that of the patients after radiotherapy, and the ICDRGPI can be used for prognosis prediction of the head and neck squamous carcinoma patients and can assist clinical radiotherapy decision-making, so that the application has good practical application value.

Description

technical field [0001] The invention belongs to the technical field of disease prognosis and molecular biology, and specifically relates to the application of immunogenic cell death-related genes in survival prognosis and radiotherapy responsiveness of head and neck squamous cell carcinoma. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Head and Neck Squamous Cell Carcinoma (HNSCC) has high morbidity and mortality, and the tumor heterogeneity is large, so there is still a lack of effective specific diagnosis. The main treatment methods for HNSCC are surgery, radiotherapy and chemotherapy, but the response rate of patients is low and the prognosis is poor. [0004] Immun...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/118C12Q2600/106
Inventor 曲迅窦宇南兆棣王克涛董召刚
Owner SHANDONG UNIV QILU HOSPITAL
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