Multifunctional prosthetic eye seat with adjustable microporous structure and its preparation method

A microporous structure and multifunctional technology, applied in the field of biomaterials and medical implants, can solve the problems of unfavorable and rapid vascularization of microstructure and chemical composition, achieve good application value, prevent and control the risk of infection, and reduce postoperative Effects of Complications

Active Publication Date: 2022-06-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the problem that the microstructure and chemical composition of existing prosthetic eye socket materials in the background technology are not conducive to rapid vascularization and to strengthen the prevention and control of various complications and side effects, the purpose of the present invention is to provide a microporous structure that can Adjustable, multifunctional prosthetic eye socket with infection prevention and control, inflammation regulation and high-efficiency promotion of vascularization and preparation method thereof

Method used

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  • Multifunctional prosthetic eye seat with adjustable microporous structure and its preparation method
  • Multifunctional prosthetic eye seat with adjustable microporous structure and its preparation method
  • Multifunctional prosthetic eye seat with adjustable microporous structure and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0046] 1) Mix tetraethyl orthosilicate, deionized water, and nitric acid in a molar ratio of 1:8:0.16, and after continuous stirring and hydrolysis for 30 minutes, add calcium nitrate and zinc nitrate reagents into the mixed solution in turn, and let the nitric acid The molar ratio of calcium, zinc nitrate, and ethyl orthosilicate is 2:1:2, continue stirring for 3 hours until the solution turns into a gel state, and then age and dry at 60 °C and 120 °C for 18 hours and 36 hours. 1250°C for 3 hours, and the obtained kesterite powder was ball-milled in an ethanol medium for 6 hours to obtain an ultrafine powder with a particle size of 10 μm or less.

[0047] 2) Weigh the ultra-fine yellow feldspar powder obtained in the above step 1) and add it to the liquid photosensitive printing resin. The mass ratio of the resin and the powder is 1:2, fully mixing by mechanical stirring, and then using digital light to process the three-dimensional printing process It is printed according to...

Embodiment 2

[0057] The preparation method is the same as that of Example 1, except that: in step 2, the internal microporous structure of the prosthetic eye seat is designed to be a Gyroid surface hole cell structure ( Figure 9 ), and in the range of 0~2.0mm, 2.0~4.0mm, 4.0~6.0mm, and the outer layer larger than 6.0mm from the center, respectively use 40% Gyroid (aperture 200μm), 60% Gyroid (aperture 300μm), 70% Gyroid (pore size 500 μm) and 80% Gyroid (pore size 600 μm) form a gradient structure with gradually increasing pore size.

Embodiment 3

[0059] The preparation method is the same as that in Example 1, except that in step 1) tetraethyl orthosilicate, deionized water, and nitric acid are mixed in a molar ratio of 1:8:0.16, and after continuous stirring and hydrolysis for 30 minutes, calcium nitrate, nitric acid The copper and zinc nitrate reagents were added to the mixed solution in turn, and the molar ratio of calcium nitrate, copper nitrate, zinc nitrate, and ethyl orthosilicate was 1.95:0.05:1:2, and stirring was continued for 5 hours until the solution was converted into coagulation. colloidal state, then aged and dried at 60 °C and 120 °C for 24 hours and 60 hours in turn, and then calcined at 1250 °C for 3 hours. Ultrafine powder below 10μm.

[0060] ICP element analysis of the copper-doped feldspar powder in this example shows that the content of copper in the powder is 1.11 ppm, and the molar ratio to the content of calcium is 1.95:0.0468, which is consistent with the theoretical value (Table 1).

[0061...

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Abstract

The invention discloses a multifunctional prosthetic eye seat with adjustable microporous structure and a preparation method thereof. It is a porous material mainly composed of undoped or heterogeneous ion-doped zinc feldspar bioceramics; the micropore scale forms a gradient pore distribution from the outside to the inside, and the micropores are connected to each other. It is a curved pore cell structure with multiple within a radius range and the micropore diameter gradually increases to form a gradient structure; mix tetraethyl orthosilicate, deionized water, and nitric acid, stir and hydrolyze, add calcium nitrate and zinc to form a gel state, age, dry, and calcinate 1. Ball milling to obtain ultrafine zinc feldspar powder; adding liquid photosensitive printing resin to form slurry, stirring and mixing for three-dimensional printing, removing residual slurry, drying and sintering to obtain the product. The prosthetic eye seat of the present invention maintains biological stability for a long time in the body, can be antibacterial, regulates inflammatory reactions and promotes angiogenesis; the structure is precise and adjustable, which is very conducive to promoting the rapid growth of vascular tissue into the pore network; the preparation process is simple, and postoperative complications are significantly reduced .

Description

technical field [0001] The invention relates to a prosthetic eye seat and a preparation method thereof in the technical field of biological materials and medical implants, in particular to a prosthetic eye seat with antibacterial, vascularization promotion, adjustable microporous structure and long-term stability and its preparation method. Background technique [0002] Enucleation is often used to treat irreversible eyeball damage caused by severe ocular trauma, endophthalmitis, intraocular tumors, and absolute glaucoma. After enucleation, combined eye socket implantation is often required to make up for the loss of orbital volume and to restore the appearance. The porous prosthetic eye seat provides support and guidance for the growth of blood vessels and soft tissues. After full vascularization, the stability of the orbit is higher, the risk of prolapse is reduced, and the probability of postoperative infection is also greatly reduced. Therefore, the porous prosthetic e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/10A61L27/54A61L27/50B33Y70/00B33Y80/00B33Y10/00A61F2/14
CPCA61L27/56A61L27/10A61L27/54A61L27/50B33Y70/00B33Y80/00B33Y10/00A61F2/141A61L2430/16A61L2300/102A61L2300/404A61L2300/41A61L2300/602A61F2240/001
Inventor 叶娟苟中入王静怡戴喜哲杨贤燕
Owner ZHEJIANG UNIV
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