Method for establishing prediction model for survival benefit of gallbladder cancer patient after chemoradiotherapy

Abstract

The invention relates to a method for establishing a prediction model for survival benefit of a gallbladder cancer patient after chemoradiotherapy. The method comprises the steps of acquiring clinical and pathological data of the gallbladder cancer patient; dividing the acquired data into a plurality of groups of data according to the TNM stages, and respectively judging whether the patient in each stage is benefited from adjuvant therapy or not; dividing the data corresponding to the TNM stages into a modeling group and an internal verification group; analyzing the prediction capability of clinical and pathological variables of the modeling group data on the total survival time OS through a single-factor COX risk scale model, and screening risk factors which significantly influence the total survival time OS of the patient in the modeling group; incorporating the screened risk factors into a multi-factor COX risk scale model for analysis, and screening out influence variables significantly influencing the total survival time OS of the patient; according to the obtained influence variables, drawing a column graph used for predicting the total survival time OS, and obtaining a prediction model; and verifying the model. Compared with the prior art, the method has the advantages of providing credible prediction and analysis results for the GBC patient, being simple and convenient to operate and the like.

Description

technical field [0001] The invention relates to the technical field of prognosis evaluation, in particular to a method for establishing a prediction model for the survival benefit of gallbladder cancer patients after radiotherapy and chemotherapy. Background technique [0002] Gallbladder cancer (GBC) is the fifth most common gastrointestinal tumor, with an annual incidence of 2 to 27 per 100,000. Although relatively rare, GBC is the most aggressive malignancy of the biliary tract, with a 5-year survival rate of approximately 5%. Surgical resection is the only treatment for GBC. However, the recurrence rate after complete resection is high, often leading to poor prognosis. Therefore, postoperative chemotherapy, chemotherapy combined with radiotherapy and other adjuvant treatments are applied to GBC patients to improve the prognosis of patients. [0003] However, due to the low incidence of GBC, the indications for adjuvant therapy for GBC and the differences in the effica...

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Problems solved by technology

[0003] However, due to the low incidence of GBC, the indications for adjuvant therapy for GBC and the differences in the efficacy of postoperative chemotherapy and chemotherapy combined with radiotherapy are still controversial.

At present, in the prior art, there is a lack of in-depth research on the differences in the efficacy of postoperative chemotherapy and chemotherapy combined with radiotherapy. At present, there is no good method to predict the prognosis of GBC patients receiving chemotherapy or chemotherapy combined with radiotherapy, and the prognosis cannot be reliably analyzed

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