Gene markers for prognosis evaluation of colorectal cancer

A technology of gene markers and colorectal cancer, which is applied in the field of medical molecular biology, can solve the problems of large background noise and achieve the effect of good discrimination ability

Active Publication Date: 2021-10-01
HUAZHONG AGRI UNIV +1
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Problems solved by technology

Although the development of high-throughput omics has produced a large amount of omics data, which has greatly increased the chances of developing effective biomarkers, the current commonly used screening strategies for tumor biomarkers are often only based on omics data, and the background noise is large, resulting in only Limited tumor markers are approved for clinical use

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  • Gene markers for prognosis evaluation of colorectal cancer
  • Gene markers for prognosis evaluation of colorectal cancer
  • Gene markers for prognosis evaluation of colorectal cancer

Examples

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Embodiment 1

[0032] Example 1: A method for screening gene markers for colorectal cancer prognosis assessment based on evolution theory, the specific screening process is:

[0033] (1) In this example, the data of colon adenocarcinoma patients (TCGA-COAD) and rectal adenocarcinoma patients (TCGA-READ) were downloaded from TCGA, and merged to obtain TCGA-CRC data. There are 521 cases in TCGA-COAD Gene expression data of patient cancer samples, of which 459 patients have clinical data (survival status, survival time) records, 399 patients have genomic variation data identified by MuTect; TCGA-READ has gene expression data of 177 patient cancer samples Among them, 171 patients have clinical data (survival status, survival time) records, and 137 patients have genomic variation data identified by the MuTect tool. The gene expression data is the gene expression level FPKM obtained by RNA-seq sequencing.

[0034] (2) The RNA-seq data of clinical patients in this example is DCH-CRC data, which is...

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Abstract

The invention discloses gene markers for prognosis evaluation of colorectal cancer. The gene markers comprise the following genes: CASP6, CLOCK, DENND6A, LARP1, SLC36A4, SERBP1, ST7L, SEC22C and USP33. The gene markers obtained through screening based on the evolution theory, correlation between cancer cells and evolution is taken into consideration in a screening process, and experiments and clinical verifications show that the expression levels of the nine gene markers can well distinguish the prognosis survival time of a colorectal cancer patient, and the gene markers can be used as effective biomarkers for prognosis evaluation of the colorectal cancer patients so as to realize effective and personalized protection and treatment of the patients; and the method for screening the gene markers for colorectal cancer prognosis evaluation based on the evolution theory can be applied to screening of other cancer prognosis gene markers. and a new thought is provided for developing effective biomarkers.

Description

technical field [0001] The invention relates to the technical field of medical molecular biology, in particular to gene markers for colorectal cancer prognosis assessment. Background technique [0002] Colorectal cancer (CRC) is the third most common cancer in the world, and its high morbidity and mortality make it an urgent matter to overcome colorectal cancer. However, although the treatment of colorectal cancer has been improved compared with the past, the insignificant early symptoms of colorectal cancer are easily overlooked by patients, and are usually diagnosed at an advanced stage, resulting in a high mortality rate of colorectal cancer No more. At present, the treatment methods for colorectal cancer generally adopt surgical resection and drug-assisted therapy, but due to the highly heterogeneous characteristics of tumors, there are great differences in the treatment effect between different patients. Therefore, effective prevention of colorectal cancer, correct di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11G16B50/00
CPCC12Q1/6886G16B50/00C12Q2600/158C12Q2600/118Y02A90/10
Inventor 张红雨曾凡新廖旋李雪全源
Owner HUAZHONG AGRI UNIV
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