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A strain with anti-aging function and its application

An anti-aging, strain technology applied in the field of microbiology to achieve the effect of enhancing muscle strength

Active Publication Date: 2022-07-22
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few studies have pointed out the relationship between aging and microbiota. Our study found that Lactobacillus (34-10B), a microbial bacterium isolated from the intestinal tract of mice, plays a significant role in anti-aging, which provides a basis for microbial regulation of aging. research Foundation

Method used

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  • A strain with anti-aging function and its application
  • A strain with anti-aging function and its application
  • A strain with anti-aging function and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 The effect of adding Bacillus velezensis SG.X-1 to drinking water on the survival rate of mice

[0037] The experiment took 6-week-old C57BL6 / J mice as a model and divided them into two groups. The control group was supplemented with physiological saline, and the experimental group was supplemented with Bacillus velezensis SG.X-1 (concentration of 5×10).5 CFU / mL), and the number of surviving mice was determined every month. The results are attached Figure 4 shown, attached by Figure 4 It can be shown that the addition of Bacillus velezensis SG.X-1 to drinking water significantly increases the survival rate of mice.

Embodiment 2

[0038] Example 2 The effect of adding Bacillus velezensis SG.X-1 to drinking water on the growth performance of aged mice

[0039] The experiment took 24-month-old C57BL6 / J mice as a model and divided them into two groups. The control group was supplemented with physiological saline, and the experimental group was supplemented with Bacillus velezensis SG.X-1 (concentration of 5×10). 5 CFU / mL). After 11 weeks, the growth performance indicators of mice were measured. The results showed that the weight of mice increased significantly after adding Bacillus velezensis SG.X-1 to drinking water. Figure 5 A; Feed intake has no effect, such as Figure 5 B. At the same time, it was found that the increase in body weight of the mice was mainly due to the increase of muscle, such as Figure 5 C; no significant effect on fat, such as Figure 5 D. This suggests that the addition of Bacillus velezensis SG.X-1 to drinking water likely increased muscle strength in mice.

Embodiment 3

[0040] Example 3 The effect of adding Bacillus velezensis SG.X-1 to drinking water on muscle strength of aged rats

[0041] The experiment took 24-month-old C57BL6 / J mice as a model and divided them into two groups. The control group was supplemented with saline, and the treatment group was supplemented with Bacillus velezensis SG.X-1 (concentration of 5×10). 5 CFU / mL). After 11 weeks, the muscle strength indexes of mice were measured, and the results showed that adding Bacillus velezensis SG.X-1 to drinking water significantly increased the suspension time of mice (such as Image 6 A), claw grip (such as Image 6 B), fast running time (such as Image 6 C) and jogging time (eg Image 6 D), showing that Bacillus velezensis SG.X-1 increases muscle strength.

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Abstract

The invention discloses a strain with anti-aging function, the strain is Bacillus velezensis SG.X-1 strain, and the strain has been preserved in the Guangdong Provincial Microorganism Culture Collection Center with the preservation number of GDMCC NO.61197, deposited on October 14, 2020. The invention also discloses the application of the strain in anti-aging of animal body. The strain of the invention has the functions of enhancing the muscle strength, cognitive learning ability, reproductive ability and antioxidant ability of the animal body, and can be used in the anti-aging of the animal body.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a bacterial strain with anti-aging function and its application. Background technique [0002] Aging is considered to be a phenomenon in which the functions of various tissues of the body are weakened and their adaptability to the environment is reduced. This is a rather complex biological process, and its regulatory mechanism is still unclear. Research views aging as the decline of a single gene or immune system, where multiple processes combine and interact at many levels, not only at the cellular and molecular levels, but also in tissues and organ systems. [0003] One of the most striking phenotypes of aging is a decline in skeletal muscle strength, which occurs in all aging individuals and results in lower extremity dysfunction and loss of mobility. The decline in muscle strength was greater than the decline in muscle mass, indicating that the contractile capacity pe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/742A61P39/06A61P21/00A61P25/28A61P15/08A23L33/135A23K10/18C12R1/07
CPCA61K35/742A61P39/06A61P21/00A61P25/28A61P15/08A23L33/135A23K10/18A23V2002/00A23V2200/302A23V2200/316A23V2200/30A23V2200/322
Inventor 束刚江青艳袁业现曾宇贤李金成
Owner SOUTH CHINA AGRI UNIV
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